From the Department of Internal Medicine I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
HSK, Clinic of Internal Medicine I, Helios-Kliniken, Wiesbaden, Germany.
ASAIO J. 2022 Jan 1;68(1):28-32. doi: 10.1097/MAT.0000000000001397.
Cardiogenic shock is associated with high mortality. Patients often require temporary mechanical circulatory support. We aimed to develop a percutaneously implantable, assist device that unloads the left ventricle (LV) in a pulsatile way. The PERkutane KATheter pump technologie (PERKAT LV) device consists of a nitinol pump chamber, which is covered by foils carrying outflow valves. A flexible tube with a pigtail-shaped tip and inflow holes represents the distal part of the pump. The system is designed for 16F percutaneous implantation. The nitinol chamber is placed in the descending aorta while the flexible tube bypasses aortic arch and ascending aorta with its tip in the LV. An intra-aortic balloon pump is placed into the chamber and connected to a console. Balloon deflation generates a blood flow from the LV into the pump chamber. During balloon inflation, blood leaves the system through the outflow foil valves in the descending aorta. Under different afterload settings using a 30 cc intra-aortic balloon pump and varying inflation/deflations rates, we recorded flow rates up to 3.0 L/min. Based on this, we believe that PERKAT LV is a promising approach for temporary LV support. The proposed design and its excellent performance give basis for in vivo tests in an animal model.
心原性休克死亡率高，患者常需临时机械循环支持。我们旨在研发一种经皮植入的、搏动性左心室（LV）辅助装置。PERkutane KATheter pump technologie（PERKAT LV）装置由一个覆盖有带有流出阀的箔片的形状记忆合金泵腔组成。一个带有猪尾状尖端和流入孔的柔性管代表泵的远端部分。该系统设计用于 16F 经皮植入。形状记忆合金腔置于降主动脉中，而柔性管绕过主动脉弓和升主动脉，其尖端置于 LV 中。一个主动脉内球囊泵置于腔室内，并与控制台相连。球囊放气时，血液从 LV 流入泵腔。在球囊充气时，血液通过降主动脉中的流出箔片阀离开系统。在使用 30cc 主动脉内球囊泵和不同充气/放气速度的不同后负荷设置下，我们记录到高达 3.0L/min 的流速。基于此，我们认为 PERKAT LV 是一种有前途的临时 LV 支持方法。该设计及其出色的性能为动物模型中的体内试验提供了基础。
