Guerci A D, Thomas K, Hess D, Halperin H R, Tsitlik J E, Wurmb E, Eitel D
Peter Belfer Laboratory for Myocardial Research, Johns Hopkins Medical Institution, Baltimore, MD.
Crit Care Med. 1988 Jun;16(6):612-4. doi: 10.1097/00003246-198806000-00010.
The relationship between transconjunctival PO2 (PcjO2) and cerebral oxygen delivery (DO2) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), DO2, and PcjO2 readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 +/- 11/25 +/- 5 (SEM) mm Hg, cerebral perfusion and DO2 fell by 53% and 57%, respectively, while PcjO2 fell by 87%. After epinephrine administration, carotid pressure increased to 128 +/- 13/48 +/- 9 mm Hg, and CBF and DO2 rose to 130% and 115% of pre-arrest levels, respectively, but PcjO2 readings remained at 11% of control values. Thus, PcjO2 failed to reflect accurately either CBF or DO2 during CPR. In the presence of epinephrine, PcjO2 does not seem to provide an accurate index of the effectiveness of CPR.
在窦性心律期间以及使用充气背心进行心肺复苏（CPR）时，对犬的经结膜氧分压（PcjO2）与脑氧输送（DO2）之间的关系进行了研究。在窦性心律期间，通过微球法测定的脑血流量（CBF）、DO2和PcjO2读数均正常。在CPR期间，颈动脉压力为82±11/25±5（SEM）mmHg时，脑灌注和DO2分别下降了53%和57%，而PcjO2下降了87%。给予肾上腺素后，颈动脉压力升至128±13/48±9 mmHg，CBF和DO2分别升至心跳骤停前水平的130%和115%，但PcjO2读数仍仅为对照值的11%。因此，在CPR期间，PcjO2未能准确反映CBF或DO2。在使用肾上腺素的情况下，PcjO2似乎无法准确反映CPR的有效性。
