Department of Neurology, LSU Health Shreveport, Shreveport, Louisiana, USA.
Center for Brain Health, LSU Health Shreveport, Shreveport, Louisiana, USA.
Alzheimers Dement. 2021 Aug;17(8):1391-1402. doi: 10.1002/alz.12305. Epub 2021 Mar 12.
While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.
虽然心脏病仍然是常见的死亡原因，但脑血管疾病随着年龄的增长而增加，并且与阿尔茨海默病和相关痴呆症（ADRD）有关。我们已经描述了硫化氢（H₂S），一种在血管稳态中起重要作用的信号分子，作为心血管疾病的生物标志物。我们假设血浆 H₂S 及其代谢物也与 ADRD 中的血管和认知功能障碍有关。我们使用分析生化方法测量血浆 H₂S 代谢物，并使用 MRI 评估 ADRD 中的微血管疾病指标。与对照组相比，ADRD 中的总 H₂S 和特定代谢物的水平增加。认知和微血管疾病指数与 H₂S 水平相关。总血浆硫化物是 ADRD 的最强指标，并部分驱动认知功能障碍与白质病变体积（微血管疾病的指标）之间的关系。我们的研究结果表明，H₂S 在痴呆症中失调，为诊断和干预提供了一个潜在的生物标志物。
