Kim So Young, Min Chanyang, Kim Hyung-Jong, Choi Hyo Geun
Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang.
Otol Neurotol. 2021 Apr 1;42(4):e408-e415. doi: 10.1097/MAO.0000000000003030.
This study aimed to investigate the relationship between thyroid function and tinnitus.
A cross-sectional study.
The Korean National Health and Nutrition Examination Survey from 2013 was used.
A total of 1,165 participants ≥ 40 years old who were surveyed for the presence of tinnitus and underwent thyroid function tests were included. The presence of discomfort from tinnitus was defined as annoying tinnitus. The control group included participants with "no tinnitus" or "no discomfort from tinnitus." The participants were divided into the annoying tinnitus group and the control group.
The associations of free thyroxine and thyroid-stimulating hormone (TSH) with annoying tinnitus were analyzed using logistic regression with complex sampling methods. Subgroup analyses were performed according to sex.
The low TSH level group had 2.35-fold greater odds of annoying tinnitus than the control group (95% confidence interval = 1.10-5.12, p = 0.027). Even in patients with a normal free thyroxine level, a low TSH level was related to 2.78-fold higher odds of annoying tinnitus (95% confidence interval = 1.21-6.38, p = 0.016). In subgroup analyses, this association was apparent in the female subgroup. The male subgroup did not show a relationship between low TSH levels and annoying tinnitus.
Subclinical hyperthyroidism was related to an increased risk of annoying tinnitus. This relationship was apparent in the female subgroup.
本研究旨在探讨甲状腺功能与耳鸣之间的关系。
横断面研究。
使用了2013年韩国国民健康与营养检查调查的数据。
纳入了1165名年龄≥40岁且接受了耳鸣检查及甲状腺功能测试的参与者。耳鸣引起的不适被定义为烦人的耳鸣。对照组包括“无耳鸣”或“无耳鸣引起的不适”的参与者。参与者被分为烦人的耳鸣组和对照组。
采用复杂抽样方法的逻辑回归分析游离甲状腺素和促甲状腺激素（TSH）与烦人的耳鸣之间的关联。按性别进行亚组分析。
低TSH水平组出现烦人的耳鸣的几率比对照组高2.35倍（95%置信区间=1.10-5.12，p=0.027）。即使在游离甲状腺素水平正常的患者中，低TSH水平也与烦人的耳鸣几率高2.78倍相关（95%置信区间=1.21-6.38，p=0.016）。在亚组分析中，这种关联在女性亚组中明显。男性亚组中低TSH水平与烦人的耳鸣之间没有关系。
亚临床甲状腺功能亢进与烦人的耳鸣风险增加有关。这种关系在女性亚组中明显。
