血浆钙浓度不同的完整大鼠和甲状腺切除大鼠的胆汁钙及胆汁酸分泌

Biliary calcium and bile acid secretion in intact and TPTX rats with varying plasma calcium concentration.

作者信息

Limlomwongse L, Deachapunya C, Krishnamra N

机构信息

Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

出版信息

Dig Dis Sci. 1988 Jun;33(6):685-91. doi: 10.1007/BF01540431.

DOI:10.1007/BF01540431

PMID:3371141

Abstract

Investigations of the effects of plasma calcium concentration on the relationship between biliary secretion of bile acid and calcium were performed in normocalcemic, calcium gluconate-induced hypercalcemic, thyroparathyroidectomy-induced hypocalcemic (TPTX) rats, and TPTX rats that received calcium gluconate to maintain normocalcemia. Studies were done at normal bile flow and at sodium taurocholate-stimulated bile flow. The results showed that biliary calcium secretion, which could occur in the absence of parathyroid hormone and calcitonin, was dependent mainly on plasma calcium concentration and was only partly influenced by bile acid secretion. Concerning the route of biliary calcium secretion, 80% was by the transcellular pathway and 20% was by the paracellular pathway. During theophylline-stimulated bile-acid-independent bile flow, the increase in bile-acid-independent calcium was found to be secreted by both pathways.

摘要

在血钙正常、葡萄糖酸钙诱导的高钙血症、甲状旁腺切除诱导的低钙血症（TPTX）大鼠以及接受葡萄糖酸钙以维持血钙正常的TPTX大鼠中，研究了血浆钙浓度对胆汁酸胆汁分泌与钙之间关系的影响。研究在正常胆汁流量和牛磺胆酸钠刺激的胆汁流量条件下进行。结果表明，在没有甲状旁腺激素和降钙素的情况下也会发生的胆汁钙分泌，主要取决于血浆钙浓度，仅部分受胆汁酸分泌的影响。关于胆汁钙分泌的途径，80%通过跨细胞途径，20%通过细胞旁途径。在茶碱刺激的不依赖胆汁酸的胆汁流动过程中，发现不依赖胆汁酸的钙增加是通过两种途径分泌的。