真菌 prenyltransferase 对花色苷的区域特异性 7-O- prenylation。
Regiospecific 7-O-prenylation of anthocyanins by a fungal prenyltransferase.
机构信息
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, People's Republic of China.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, People's Republic of China; Xiangya Hospital of Central South University, Changsha 410008, People's Republic of China.
出版信息
Bioorg Chem. 2021 May;110:104787. doi: 10.1016/j.bioorg.2021.104787. Epub 2021 Mar 2.
Anthocyanins are a type of well-known natural flavonoids for their various beneficial health effects. However, prenylated anthocyanins are not discovered in nature although prenylation is believed to generally enhance the biological accessibility of flavonoids. In this article, we demonstrate the first example for prenylation of anthocyanins. A chemo-enzymatic approach was achieved for the synthesis of a series of 7-O-prenylated anthocyanins, using the fungal prenyltransferase CdpC3PT from Neosartorya fischeri.
花色苷是一种众所周知的天然类黄酮，具有多种有益的健康功效。然而，尽管人们普遍认为类黄酮的 prenylation 通常会增强其生物可及性，但天然产物中尚未发现 prenylated 花色苷。在本文中，我们展示了花色苷 prenylation 的第一个例子。使用来自 Neosartorya fischeri 的真菌 prenyltransferase CdpC3PT，通过化学-酶法合成了一系列 7-O-prenylated 花色苷。
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