Unit of Cognitive Disorders and Dementia, Neuroscience Department, San Camillo Hospital, Rome, Italy.
Unit of Cognitive Disorders and Dementia, Neuroscience Department, San Camillo Hospital, Rome, Italy.
Cortex. 2021 May;138:178-190. doi: 10.1016/j.cortex.2021.02.004. Epub 2021 Feb 17.
Craniopharyngiomas (CP's) are hypothalamic tumors often associated with psychological disorders. Nevertheless, its diagnosis is still challenging when psychiatric disorders are not associated with any other neurological symptoms. This single-case study describes a patient with a history of bipolar disorder before a diagnosis of a large CP arising the sellar and suprasellar region was posed. At the time of the present study the patient showed emotional/behavioral disorders and Korsakoff-like amnesia, that completely recovered after surgical resection of the tumor. This is one of those few cases described in literature, who presented cognitive/behavioral disorders because the compression of the diencephalic structures due to CP mass effect. This case offers further evidence on the functional neuroanatomy of the hypothalamus and its pathways.
颅咽管瘤（CP）是下丘脑肿瘤，常与心理障碍有关。然而，当精神障碍与任何其他神经症状无关时，其诊断仍然具有挑战性。本病例研究描述了一位患者，他在被诊断为大型 CP 之前，曾有双相情感障碍病史，该 CP 起源于蝶鞍和鞍上区域。在本研究时，患者表现出情绪/行为障碍和柯萨科夫样遗忘症，在肿瘤切除后完全恢复。这是文献中描述的少数几个因 CP 肿块效应导致间脑结构受压而出现认知/行为障碍的病例之一。该病例为下丘脑及其通路的功能神经解剖学提供了进一步的证据。
