Mutational spectrum of -mutated acute myeloid leukemia patients older than 75 years.

AML with mutated occurs in all age groups. Yet, the mutational pattern is not extensively studied in the very old, which may hamper appropriate risk assessment. Herein we examined 22 cases of -mutated AML in patients older than 75, with a median age of 84. All diagnostic samples were sequenced aiming for coverage of the most relevant AML-associated mutations. For comparison with younger patients, we used already published data on several cohorts. A total of 76 mutations including 50 different variants were identified in 16 recurrently mutated AML genes. Compared with younger patients, a significant enrichment of and was observed, together with a reduced frequency of mutations. Our results indicate that the mutational pattern may be different in the very old as compared to younger patients with -mutated AML.HighlightsThe mutational spectrum of -mutated AML in patients above 75 years displays distinct features.A significant enrichment of and mutations together with a reduced frequency of mutations was observed in the elderly. mutation is a secondary event in the development of AML in the very old.