可能由胆碱酯酶抑制剂类杀虫剂诱发的张力障碍反应。
Dystonic reaction possibly induced by cholinesterase inhibitor insecticides.
作者信息
Moody S B, Terp D K
机构信息
Department of Pharmaceutical Services, Providence Hospital, Southfield, Michigan 48075.
出版信息
Drug Intell Clin Pharm. 1988 Apr;22(4):311-2. doi: 10.1177/106002808802200408.
A 39-year-old male presented to the emergency room following parenteral injection of a household insecticide. The patient suffered from delayed, local complications as well as a dystonic-like reaction involving the neck musculature that was relieved by intramuscular diphenhydramine. Exposure to cholinesterase inhibitor insecticides has been associated with a number of serious toxicities due to accumulation of acetylcholine at various sites. It has been suggested that dystonic reactions are caused by an imbalance between cholinergic and dopaminergic pathways in the central nervous system. Therefore, a possible explanation of the dystonic reaction in this case is the increased cholinergic activity relative to dopaminergic activity induced by the insecticide.
一名39岁男性在经肠胃外注射家用杀虫剂后被送往急诊室。该患者出现了延迟性局部并发症以及涉及颈部肌肉组织的肌张力障碍样反应，肌肉注射苯海拉明后症状得到缓解。由于乙酰胆碱在各个部位的蓄积，接触胆碱酯酶抑制剂类杀虫剂与多种严重毒性相关。有人提出，肌张力障碍反应是由中枢神经系统中胆碱能和多巴胺能通路之间的失衡引起的。因此，该病例中肌张力障碍反应的一个可能解释是，杀虫剂诱导的胆碱能活性相对于多巴胺能活性增加。
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