Department of Epizootiology and Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 30 Głęboka St. 20-612, Lublin, Poland.
Veterinary Clinic "Teodorowscy" in Mikołów, Mikołów, Poland.
BMC Vet Res. 2021 Mar 12;17(1):118. doi: 10.1186/s12917-021-02827-8.
Anaplasma are obligate intracellular bacteria and aetiological agents of tick-borne diseases of both veterinary and medical interest. The genus Anaplasma comprises six species: Anaplasma marginale, Anaplasma centrale, Anaplasma ovis, Anaplasma phagocytophilum, Anaplasma bovis and Anaplasma platys. They can infect humans, carnivores, ruminants, rodents, insectivores, birds and reptiles. The aim of this study was to present the first clinical case of granulocytic anaplasmosis in a captive ring-tailed lemur in Poland.
A 4-year-old female lemur presented anorexia, epistaxis and tick infestation. The microscopic examination of a blood smear revealed morulae in neutrophils. Polymerase chain reaction test and sequencing of obtained PCR product confirmed infection by the GU183908 Anaplasma phagocytophilum strain. Therapeutic protocol included doxycycline (2.5 mg/kg p.o., b.i.d.) for 3 weeks and the lemur recovered within 24 h.
This is the first report on granulocytic anaplasmosis in a ring-tailed lemur in Europe, indicating that A. phagocytophilum infection must also be considered in differential diagnosis in this animal species, especially in individuals with thrombocytopenia associated with Ixodes ricinus parasitism.
无形体属（Anaplasma）是专性细胞内细菌，也是具有兽医和医学意义的蜱传疾病的病原体。该属包括六种物种：边缘无形体（Anaplasma marginale）、中央无形体（Anaplasma centrale）、绵羊无形体（Anaplasma ovis）、嗜吞噬细胞无形体（Anaplasma phagocytophilum）、牛无形体（Anaplasma bovis）和宽体无形体（Anaplasma platys）。它们可以感染人类、食肉动物、反刍动物、啮齿动物、食虫动物、鸟类和爬行动物。本研究旨在报告波兰首例圈养环尾狐猴粒细胞无形体病的临床病例。
一只 4 岁雌性狐猴出现厌食、鼻出血和蜱虫感染。血涂片的显微镜检查显示中性粒细胞中有嗜锇小体。聚合酶链反应（PCR）检测和获得的 PCR 产物测序证实感染了 GU183908 型嗜吞噬细胞无形体。治疗方案包括多西环素（2.5 mg/kg，口服，每日两次）治疗 3 周，狐猴在 24 小时内康复。
这是欧洲首例关于环尾狐猴粒细胞无形体病的报告，表明嗜吞噬细胞无形体感染也必须在该动物物种的鉴别诊断中考虑，尤其是在伴有蜱虫寄生相关血小板减少症的个体中。
