Lewis K J, Molan P C, Bass J J, Gluckman P D
Department of Biological Sciences, University of Waikato, Hamilton, New Zealand.
Endocrinology. 1988 Jun;122(6):2554-7. doi: 10.1210/endo-122-6-2554.
Insulin-like growth factor I (IGF-I) at concentrations of 40 ng/ml is lipogenic in ovine adipose tissue slices in vitro. Neither human IGF-II (hIGF-II) or rat IGF-II (rIGF-II) [multiplication-stimulating activity (MSA)] is lipogenic at similar concentrations. However, when present at lower concentrations recombinant human IGF-I (rhIGF-I) (400 pg/ml), hIGF-II (0.4 pg/ml), and MSA (40 pg/ml) were lipolytic. As IGF-II appeared more potent than IGF-I in promoting lipolysis, this effect may be mediated via the type 2 IGF receptor. The lipolytic effect of GH may be partly due to the actions of IGFs released locally.
胰岛素样生长因子I（IGF-I）浓度为40 ng/ml时，在体外绵羊脂肪组织切片中具有生脂作用。人胰岛素样生长因子II（hIGF-II）或大鼠胰岛素样生长因子II（rIGF-II）[促增殖活性（MSA）]在相似浓度下均无生脂作用。然而，当以较低浓度存在时，重组人胰岛素样生长因子I（rhIGF-I）（400 pg/ml）、hIGF-II（0.4 pg/ml）和MSA（40 pg/ml）具有脂解作用。由于IGF-II在促进脂解方面似乎比IGF-I更有效，这种作用可能是通过2型IGF受体介导的。生长激素的脂解作用可能部分归因于局部释放的IGF的作用。
