Department of Ophthalmology, JA Hiroshima General Hospital, Hiroshima, Japan.
Department of Ophthalmology and Visual Science, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Sci Rep. 2021 Mar 12;11(1):5812. doi: 10.1038/s41598-021-85271-w.
We examined responsiveness to ripasudil as a potential factor for predicting the effect of selective laser trabeculoplasty (SLT) when performed for primary open-angle glaucoma (POAG). A total of 70 eyes with no history of glaucoma surgery underwent SLT between January 2015 and June 2019. Patients were divided into two groups, with an intraocular pressure (IOP) decrease of 15% or more due to ripasudil administration before SLT defined as the effective group, while an IOP decrease of less than 15% was defined as the non-effective group. Kaplan-Meier survival analysis was performed. A Cox proportional hazards model assessed the influence of baseline factors on the success. Of the 70 eyes evaluated, treatments were effective in 22 and non-effective in 48. Postoperatively, both groups exhibited IOP reductions for up to 24 months. Success ratios at 12 and 24 months after SLT were 43.5% and 18.5% in the effective versus 24.9% and 9.3% in the non-effective group, which were significantly higher in the effective group (P = 0.03). Presence of a ripasudil effective eye (P = 0.03) was associated with treatment success. Responsiveness to ripasudil may be useful in predicting the therapeutic effect of SLT.
我们研究了 ripasudil 的反应性是否可以作为预测选择性激光小梁成形术（SLT）治疗原发性开角型青光眼（POAG）效果的潜在因素。2015 年 1 月至 2019 年 6 月期间，共有 70 例无青光眼手术史的患者接受了 SLT。将 SLT 前因 ripasudil 给药而眼压（IOP）降低 15%或更多的患者分为有效组，而将 IOP 降低不足 15%的患者分为无效组。进行 Kaplan-Meier 生存分析。Cox 比例风险模型评估了基线因素对成功率的影响。在评估的 70 只眼中，22 只眼的治疗有效，48 只眼的治疗无效。术后两组均在 24 个月内降低了 IOP。SLT 后 12 个月和 24 个月的成功率分别为有效组的 43.5%和 18.5%，以及无效组的 24.9%和 9.3%，有效组明显更高（P = 0.03）。存在 ripasudil 有效眼（P = 0.03）与治疗成功相关。对 ripasudil 的反应性可能有助于预测 SLT 的治疗效果。
