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使用英国医院事件统计数据评估腹疝工作组分类法的长期结果:一项人群研究。

Evaluation of the Ventral Hernia Working Group classification for long-term outcome using English Hospital Episode Statistics: a population study.

作者信息

Hodgkinson J D, Worley G, Warusavitarne J, Hanna G B, Vaizey C J, Faiz O D

机构信息

Department of Colorectal Surgery, St Mark's Hospital and Academic Institute, Watford Road, Harrow, London, HA1 3UJ, UK.

Department of Surgery and Cancer, Imperial College London, London, UK.

出版信息

Hernia. 2021 Aug;25(4):977-984. doi: 10.1007/s10029-021-02379-8. Epub 2021 Mar 13.

Abstract

PURPOSE

The Ventral Hernia Working Group (VHWG) classification of ventral/incisional hernia (IH) was developed by expert consensus in 2010. Subsequently, Kanters et al. have demonstrated the validity of a modified version of the system for predicting short-term outcomes. This study aims to evaluate the modified system for predicting hernia recurrence.

METHODS

Patients undergoing IH surgery (defined by OPCS codes) in the England Hospital Episode Statistics (HES) database, from 1997 to 2012, were identified. Baseline demographics at index hernia operation and episodes of further hernia surgery (FHS) were recorded. Risk factors for FHS were identified using cox regression and evaluated against the modified-VHWG grade using receiver-operating characteristics (ROC).

RESULTS

The final analysis included 214,082 index IH operations. Of these, 52.6% were female and mean age was 56.59 (SD15.9). An admission for FHS was found in 8.3% cases (17,714 patients). Multi-variate cox regression revealed contaminated hernia (p < 0.0001), pre-existing IBD (p < 0.0001) and hernia comorbidity (p = 0.05) to be significantly related to long-term FHS. Classifying patients using these factors, according to the modified-VHWG classification, revealed that compared to Grade 1, the hazard ratio (HR) of FHS increased in Grade 2 (HR 1.19; p < 0.0001) and further increased in Grade 3 (HR 1.79; p < 0.0001). ROC analysis revealed the area under the curve to be 0.73 (95% CI 0.73-0.74).

CONCLUSION

This analysis demonstrates the broad validity of the modified-VHWG classification in discriminating risk for FHS. Inclusion of pre-existing IBD as a factor defining Grade 2 patients would be recommended. This analysis is limited by the absence of certain factors within the HES database, such as BMI.

摘要

目的

腹疝工作组(VHWG)对腹侧/切口疝(IH)的分类于2010年通过专家共识制定。随后,坎特斯等人证明了该系统的一个修改版本在预测短期结果方面的有效性。本研究旨在评估该修改后的系统对疝复发的预测能力。

方法

在英格兰医院事件统计(HES)数据库中识别1997年至2012年接受IH手术(由OPCS编码定义)的患者。记录初次疝手术时的基线人口统计学数据以及进一步疝手术(FHS)的发作情况。使用cox回归确定FHS的危险因素,并使用受试者工作特征(ROC)针对修改后的VHWG分级进行评估。

结果

最终分析包括214,082例初次IH手术。其中,52.6%为女性,平均年龄为56.59(标准差15.9)。8.3%的病例(17,714名患者)因FHS入院。多变量cox回归显示污染疝(p<0.0001)、既往炎症性肠病(IBD)(p<0.0001)和疝合并症(p = 0.05)与长期FHS显著相关。根据修改后的VHWG分类,使用这些因素对患者进行分类,结果显示与1级相比,2级FHS的风险比(HR)增加(HR 1.19;p<0.0001),3级进一步增加(HR 1.79;p<0.0001)。ROC分析显示曲线下面积为0.73(95%CI 0.73 - 0.74)。

结论

该分析证明了修改后的VHWG分类在区分FHS风险方面具有广泛的有效性。建议将既往IBD纳入定义2级患者的因素中。本分析受到HES数据库中某些因素(如BMI)缺失的限制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d394/8370963/b8ec48a239c9/10029_2021_2379_Fig1_HTML.jpg

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