Department of Bioengineering, Huainan Normal University, Huainan, China.
Key Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, Huainan Normal University, Huainan, China.
J Sci Food Agric. 2021 Oct;101(13):5627-5635. doi: 10.1002/jsfa.11215. Epub 2021 Mar 25.
Nanoparticles can improve the bioavailability of bioactive compounds. Concomitant intake of food can affect pharmacokinetic profiles by altering dissolution, absorption, metabolism, and elimination behavior. Studies on the effects of food and its supplements on the bioavailability of bioactives in nanoformulations are few. In this study, the effects of typical food (milk, sugar, high-fat diet, and regular kibble) and a widely consumed probiotic [Bifidobacterium lactis Bb-12® (Bb-12)] on the bioavailability of curcumin in four formulations [simply suspended curcumin (Cur-SS) and curcumin in nanoemulsions (Cur-NEs), in single-walled carbon nanotubes (Cur-SWNTs), and in nanostructured lipid carriers (Cur-NLCs)] were investigated.
Fasting treatment and sugar co-ingestion can significantly enhance the bioavailability of curcumin in Cur-NEs and Cur-SWNTs, respectively. Compared with the fasting treatment, co-ingestion with regular kibble reduced the absorption of curcumin in Cur-NEs and Cur-SWNTs. Ingesting milk along with Cur-NE is also not recommended. The mechanisms behind these phenomena were briefly discussed. This study revealed for the first time that the intestinal colonization of Bb-12 reduces the bioavailability of curcumin and this reduction can be attenuated by nanoformulations SWNTs and NLCs, but not NEs. The reason for this difference was the protective effects of the former two nanoformulations against curcumin degradation by Bb-12 according to in vitro experiments.
Dietary status (including supplementary probiotics) can dramatically influence the bioavailability of curcumin in nanoformulations. © 2021 Society of Chemical Industry.
纳米粒子可以提高生物活性化合物的生物利用度。同时摄入食物会通过改变溶解、吸收、代谢和消除行为来影响药代动力学特征。关于食物及其补充剂对纳米制剂中生物活性物质生物利用度的影响的研究很少。在这项研究中，考察了典型食物（牛奶、糖、高脂肪饮食和普通颗粒饲料）和一种广泛食用的益生菌[双歧杆菌 Bb-12（Bb-12）]对四种制剂中姜黄素生物利用度的影响[简单悬浮姜黄素（Cur-SS）和纳米乳液中的姜黄素（Cur-NE）、单壁碳纳米管中的姜黄素（Cur-SWNTs）和纳米结构脂质载体中的姜黄素（Cur-NLCs）]。
禁食处理和糖共摄入可显著提高 Cur-NE 和 Cur-SWNTs 中姜黄素的生物利用度。与禁食处理相比，与普通颗粒饲料共摄入会降低 Cur-NE 和 Cur-SWNTs 中姜黄素的吸收。也不建议将牛奶与 Cur-NE 一起服用。简要讨论了这些现象背后的机制。本研究首次揭示，Bb-12 的肠道定植会降低姜黄素的生物利用度，而纳米制剂 SWNTs 和 NLCs 可以减轻这种降低，但 NE 制剂则不行。根据体外实验，这种差异的原因是前两种纳米制剂对 Bb-12 降解姜黄素的保护作用。
饮食状况（包括补充益生菌）会极大地影响纳米制剂中姜黄素的生物利用度。© 2021 化学工业协会。
