Life Science Research Centre, Faculty of Science, University of Ostrava, 702 00 Ostrava, Czech Republic.
Halil Bayraktar Health Vocational College, Erciyes University, 38030 Kayseri, Turkey.
Acta Trop. 2021 Jun;218:105888. doi: 10.1016/j.actatropica.2021.105888. Epub 2021 Mar 11.
In this study, we characterized a collection of clinical samples obtained from Syrian and Turkish patients with cutaneous leishmaniasis using internal transcribed spacer 1 (ITS1) sequences. All obtained sequences belonged to Leishmania tropica. Combining them with those available from GenBank allowed us performing a broad-scale analysis of genetic diversity for this species. We demonstrated that L. tropica has a complex phylogeographic pattern with some haplotypes being widespread across endemic countries and others restricted to particular regions. We hypothesize that at least some of them may be associated with alternative vectors or animal reservoirs.
在这项研究中，我们使用内部转录间隔区 1（ITS1）序列对来自叙利亚和土耳其皮肤利什曼病患者的临床样本进行了特征描述。所有获得的序列均属于利什曼原虫热带种。将它们与来自 GenBank 的序列相结合，使我们能够对该物种的遗传多样性进行广泛分析。我们证明，利什曼原虫热带种具有复杂的系统地理格局，一些单倍型广泛分布于流行国家，而另一些则局限于特定地区。我们假设，其中至少有一些可能与替代媒介或动物宿主有关。
