氨基酸酰基麦角固醇的合成：真菌的一种新型脂质成分。
Synthesis of aminoacylated ergosterols: A new lipid component of fungi.
机构信息
Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan.
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32826, USA.
出版信息
Steroids. 2021 May;169:108823. doi: 10.1016/j.steroids.2021.108823. Epub 2021 Mar 11.
Aminoacylated ergosterol such as 1-ergosteryl aspartate (Erg-Asp) is a new lipid component recently discovered in fungi. In order to study physiological functions of this novel sterol derivative and to develop potential antifungal agents, we established the method to synthesize aminoacylated ergosterol derivatives. Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.
酰化麦角甾醇，如 1-麦角甾醇天冬氨酸（Erg-Asp），是最近在真菌中发现的一种新型脂质成分。为了研究这种新型固醇衍生物的生理功能并开发潜在的抗真菌剂，我们建立了合成酰化麦角甾醇衍生物的方法。在此，我们报告了使用 Boc 保护氨基酸合成 Erg-Asp 以及其他一些酰化麦角甾醇（Erg-Gly、Erg-Ala、Erg-Leu、Erg-Ile 和 Erg-Val）的方法。
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