胆囊收缩素拮抗剂L-364,718在体内可抑制胆囊收缩素对大鼠胰腺分泌的作用，但不抑制蛙皮素的作用。
The cholecystokinin antagonist L-364,718 inhibits the action of cholecystokinin but not bombesin on rat pancreatic secretion in vivo.
作者信息
Anderson L, Dockray G J
机构信息
Physiological Laboratory, University of Liverpool, U.K.
出版信息
Eur J Pharmacol. 1988 Feb 9;146(2-3):307-11. doi: 10.1016/0014-2999(88)90307-x.
PMID:3371402
Abstract
The action of an antagonist of peripheral CCK receptors, L-364,718 on CCK8 and bombesin-induced pancreatic exocrine secretion was studied in anaesthetized rats. Both CCK8 and bombesin increased the rate of flow and rate of enzyme secretion from the pancreas. Intravenous L-364,718 inhibited the actions of CCK8, but not those of bombesin. It is concluded that bombesin acts on the exocrine pancreas directly rather than through the release of CCK.
摘要
在麻醉大鼠中研究了外周CCK受体拮抗剂L-364,718对CCK8和蛙皮素诱导的胰腺外分泌的作用。CCK8和蛙皮素均增加了胰腺的分泌流速和酶分泌速率。静脉注射L-364,718可抑制CCK8的作用，但不抑制蛙皮素的作用。结论是蛙皮素直接作用于胰腺外分泌腺，而不是通过释放CCK起作用。
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