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Neuraxial opioid-induced itch and its pharmacological antagonism.神经轴索阿片类药物引起的瘙痒及其药理学拮抗作用。
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Hypotension and pruritus induced by neuraxial anaesthesia in a cat.猫蛛网膜下腔麻醉引起的低血压和瘙痒
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[Opioid-induced pruritus. Mechanisms and treatment regimens].[阿片类药物引起的瘙痒。机制与治疗方案]
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STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice.STING 通过脊髓罐结合激酶 1 依赖性 I 型干扰素反应控制小鼠的阿片类药物诱导性瘙痒和慢性瘙痒。
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本文引用的文献

1
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition.吗啡通过去抑制作用作用于脊髓强啡肽神经元而引起瘙痒。
Sci Transl Med. 2021 Feb 3;13(579). doi: 10.1126/scitranslmed.abc3774.
2
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.中枢阿片受体通过去抑制介导吗啡诱导的瘙痒和慢性瘙痒。
Brain. 2021 Mar 3;144(2):665-681. doi: 10.1093/brain/awaa430.
3
Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.背角神经元图谱定义了其结构，并将感觉输入与转录细胞类型联系起来。
Nat Neurosci. 2018 Jun;21(6):869-880. doi: 10.1038/s41593-018-0141-1. Epub 2018 Apr 23.
4
Gate control of mechanical itch by a subpopulation of spinal cord interneurons.脊髓中间神经元亚群对机械性瘙痒的门控作用。
Science. 2015 Oct 30;350(6260):550-4. doi: 10.1126/science.aac8653.
5
Neuraxial opioid-induced itch and its pharmacological antagonism.神经轴索阿片类药物引起的瘙痒及其药理学拮抗作用。
Handb Exp Pharmacol. 2015;226:315-35. doi: 10.1007/978-3-662-44605-8_17.
6
Neuraxial opioid-induced pruritus: An update.神经轴索阿片类药物引起的瘙痒：最新进展
J Anaesthesiol Clin Pharmacol. 2013 Jul;29(3):303-7. doi: 10.4103/0970-9185.117045.
7
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.孤啡肽受体 MOR1D 通过单向交叉激活胃泌酸调节素受体，使阿片类药物诱导的瘙痒和镇痛分离。
Cell. 2011 Oct 14;147(2):447-58. doi: 10.1016/j.cell.2011.08.043.
8
Molecular insights into mu opioid pharmacology: From the clinic to the bench.分子水平认识μ阿片类药物药理学：从临床到实验室。
Clin J Pain. 2010 Jan;26 Suppl 10(Suppl 10):S3-9. doi: 10.1097/AJP.0b013e3181c49d2e.
9
The neurobiology of itch.瘙痒的神经生物学
Nat Rev Neurosci. 2006 Jul;7(7):535-47. doi: 10.1038/nrn1950.
10
Neuraxial opioid-induced pruritus: a review.神经轴索阿片类药物引起的瘙痒：综述
J Clin Anesth. 2003 May;15(3):234-9. doi: 10.1016/s0952-8180(02)00501-9.

Mechanistic insights into spinal neurones involved in neuraxial opioid-induced pruritus.

作者信息

Nguyen Eileen, Lim Grace, Ross Sarah E

机构信息

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Medical Scientist Training Programme, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Department of Anaesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Obstetrics, Gynaecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

出版信息

Br J Anaesth. 2021 May;126(5):e179-e181. doi: 10.1016/j.bja.2021.02.009. Epub 2021 Mar 11.

DOI:10.1016/j.bja.2021.02.009
PMID:33714534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8176652/
Abstract
摘要