Ludwig Boltzmann Institute for experimental and clinical traumatology, Vienna, Austria; AUVA Trauma Center Meidling, Vienna, Austria; AUVA trauma research center, Vienna, Austria; Austrian Cluster for Tissue Engineering, Vienna, Austria.
Ludwig Boltzmann Institute for experimental and clinical traumatology, Vienna, Austria; Clinic Floridsdorf, Orthopedic and Traumatology Department, Vienna, Austria.
Injury. 2021 Jun;52 Suppl 2:S84-S90. doi: 10.1016/j.injury.2021.02.081. Epub 2021 Mar 2.
Extracorporeal shockwave therapy is a treatment modality, originally introduced into the clinic as lithotripsie, which has also been successfully used in the last two decades in the non-invasive treatment of delayed or non-healing fractures. Initially, the mechanism of action was attributed to microfracture-induced repair, but intensive basic research has now shown that the shockwave generates its effect in tissue via mechanotransduction. Numerous signal transduction pathways have already been demonstrated, which in their entirety trigger an endogenous regeneration process via cell proliferation, migration and differentiation. Clinically, these shockwave-conveyed biological signals support healing of acute, delayed and non-union fractures. The attainable outcome is comparable to surgery but avoiding an open approach with associated potential complications. These advantageous properties with a clearly positive cost-benefit ratio make shockwave therapy a first line treatment in delayed and non-union fractures.
体外冲击波疗法是一种治疗方式，最初作为碎石术引入临床，在过去二十年中也已成功用于延迟或不愈合骨折的非侵入性治疗。最初，作用机制归因于微骨折诱导的修复，但深入的基础研究现在表明，冲击波通过机械转导在组织中产生其作用。已经证明了许多信号转导途径，它们通过细胞增殖、迁移和分化的整体触发内源性再生过程。临床上，这些冲击波传递的生物学信号支持急性、延迟和不愈合骨折的愈合。可达到的结果与手术相当，但避免了潜在并发症相关的开放式方法。这些具有明显正成本效益比的有利特性使冲击波治疗成为延迟和不愈合骨折的一线治疗方法。
