体外冲击波疗法对骨折愈合的影响及其作用机制。
The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing.
机构信息
Department of Rehabilitation Medicine, First Hospital of Jilin University, Chang chun, China.
出版信息
Front Endocrinol (Lausanne). 2023 May 24;14:1188297. doi: 10.3389/fendo.2023.1188297. eCollection 2023.
Abstract
The clinical efficacy of ESWT in treating bone non union has been widely recognized, but the biological mechanism of ESWT promoting bone non union healing is still unclear. ESWT can make old callus micro fracture through mechanical conduction, form subperiosteal hematoma, promote the release of bioactive factors, reactivate the fracture healing mechanism, rebalance the activities of osteoblasts and osteoclast, promote the angiogenesis of fracture site, and accelerate the healing of bone nonunion.Over recent years, great efforts have been made by both scientists and clinicians to explore the underlying mechanism behind the healing effect of ESWT on bone fractures. In this review, we introduced the growth factors during osteogenesis induced by ESWT hoping to provide new insights in the clinical use of ESWT.
摘要
体外冲击波治疗（ESWT）在治疗骨不连方面的临床疗效已得到广泛认可，但 ESWT 促进骨不连愈合的生物学机制尚不清楚。ESWT 可以通过机械传导使陈旧性骨痂微骨折，形成骨膜下血肿，促进生物活性因子的释放，重新激活骨折愈合机制，重新平衡成骨细胞和破骨细胞的活性，促进骨折部位的血管生成，加速骨不连的愈合。近年来，科学家和临床医生都在努力探索 ESWT 治疗骨折愈合效果的潜在机制。在这篇综述中，我们介绍了 ESWT 诱导成骨过程中的生长因子，希望为 ESWT 的临床应用提供新的见解。
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