ENT Research Lab, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of São Paulo, São Paulo, SP, Brazil.
Otorhinolaryngology Department, São Paulo University, São Paulo, SP, Brazil.
Eur Arch Otorhinolaryngol. 2021 Nov;278(11):4335-4343. doi: 10.1007/s00405-021-06722-8. Epub 2021 Mar 13.
Chronic rhinosinusitis without nasal polyposis (CRSsNP) and Chronic rhinosinusitis with nasal polyposis (CRSwNP) present distinct tissue remodeling processes. The proteins involved in the process of tissue remodeling have their production and activity related to the inflammatory environment they are. This study aimed to evaluate the protein expression of BMP-7, MMP-9, TGF-β in chronic sinusitis with and without nasal polyposis and their relations with IL-6 and IL-10.
Cross-sectional observational study with 86 participants was divided into three groups: patients with CRSwNP (n = 34), patients with CRSsNP (n = 26), and a control group (CG) without inflammatory disease of the nasal mucosa (n = 26). The primary outcomes were the concentrations of BMP-7, MMP-9, TGF-β, IL-6, and IL-10. Secondary outcomes were the correlations of these markers.
The TGF-β dosage was elevated in the CRSsNP group and reduced in the CSwNP group. The dosage of IL-6 was higher in the CSwNP group, and the IL-10 dosage lower in the groups with sinusitis, and IL-10 was positively correlated with BMP-7 in all groups. There was a negative correlation between IL-6 and IL-10 in all groups observed. The correlation between MMP-9 and interleukins was lost in the CRSsNP group. There was a positive correlation between TGF-β and IL-6 in the CG, and negative in the CRSsNP group.
An inflammation shown in rhinosinusitis with an increase in IL-6 and decrease in IL-10 when compared with the control group; only TGF-β was altered in the tissue remodeling process when compared with BMP-7 and MMP-9 in rhinosinusitis. There is a loss of correlation between tissue remodeling proteins and interleukins studied in CRSsNP.
慢性鼻-鼻窦炎不伴鼻息肉（CRSsNP）和慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）表现出不同的组织重塑过程。参与组织重塑过程的蛋白的产生和活性与其所处的炎症环境有关。本研究旨在评估骨形态发生蛋白 7（BMP-7）、基质金属蛋白酶 9（MMP-9）和转化生长因子-β（TGF-β）在伴或不伴鼻息肉的慢性鼻窦炎中的蛋白表达及其与白细胞介素 6（IL-6）和白细胞介素 10（IL-10）的关系。
采用横断面观察性研究，共纳入 86 名参与者，分为三组：CRSwNP 患者（n=34）、CRSsNP 患者（n=26）和无鼻腔黏膜炎症的对照组（CG）（n=26）。主要结局为 BMP-7、MMP-9、TGF-β、IL-6 和 IL-10 的浓度。次要结局为这些标志物的相关性。
CRSsNP 组 TGF-β 水平升高，CRSwNP 组 TGF-β 水平降低。CRSwNP 组 IL-6 水平较高，两组鼻窦炎患者的 IL-10 水平较低，且所有组中 IL-10 与 BMP-7 呈正相关。所有组均观察到 IL-6 与 IL-10 呈负相关。CRSsNP 组 MMP-9 与白细胞介素的相关性丧失。CG 中 TGF-β 与 IL-6 呈正相关，而 CRSsNP 组则呈负相关。
与对照组相比，伴鼻息肉的鼻-鼻窦炎显示出炎症，IL-6 增加，IL-10 减少；与 BMP-7 和 MMP-9 相比，鼻-鼻窦炎中的组织重塑过程仅改变了 TGF-β。在 CRSsNP 中，研究的组织重塑蛋白与白细胞介素之间的相关性丧失。
