Koch T R, Carney J A, Go V L, Szurszewski J H
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota.
Gastroenterology. 1988 Jul;95(1):77-84. doi: 10.1016/0016-5085(88)90293-4.
Spontaneous contractions, inhibitory responses produced by electrical field stimulation, and some electrophysiologic properties of circular smooth muscle from normal sigmoid colon and from sigmoid colon of ulcerative colitis patients were compared in vitro using simultaneous recordings of mechanical and intracellular electrical activity. In normal colonic circular muscle obtained from 21 patients, the frequency of spontaneous summation contractions ranged from 3 to 7 per 4 min, whereas in circular muscle from 13 patients with ulcerative colitis, the frequency of these contractions ranged from 1 to 9 per 4 min. Nonadrenergic, noncholinergic relaxation produced by electrical field stimulation was recorded in the majority of circular smooth muscle strips from both normal colon and colon from patients with ulcerative colitis. There were no significant differences in mean resting membrane potential, mean slow-wave frequency, mean maximum slow-wave amplitude, or inhibitory-junction potential amplitudes recorded using circular smooth muscle from both normal colon and colon from patients with ulcerative colitis. There appeared to be a weak association in patients with ulcerative colitis between increasing duration of symptoms and decreasing frequency of spontaneous summation contractions, but there were no associations between the frequency of these contractions and the severity of colonic inflammation, patient age, or the frequency of stools. The mechanism accounting for a wider range in the frequency of summation contractions recorded from colonic circular smooth muscle in ulcerative colitis remains to be determined.
利用机械和细胞内电活动的同步记录，在体外比较了正常乙状结肠和溃疡性结肠炎患者乙状结肠环形平滑肌的自发收缩、电场刺激产生的抑制反应以及一些电生理特性。在从21例患者获取的正常结肠环形平滑肌中，自发总和收缩的频率为每4分钟3至7次，而在13例溃疡性结肠炎患者的环形平滑肌中，这些收缩的频率为每4分钟1至9次。在大多数来自正常结肠和溃疡性结肠炎患者结肠的环形平滑肌条中，均记录到了电场刺激产生的非肾上腺素能、非胆碱能舒张。使用正常结肠和溃疡性结肠炎患者结肠的环形平滑肌记录的平均静息膜电位、平均慢波频率、平均最大慢波幅度或抑制性接头电位幅度均无显著差异。在溃疡性结肠炎患者中，症状持续时间增加与自发总和收缩频率降低之间似乎存在弱关联，但这些收缩的频率与结肠炎症的严重程度、患者年龄或排便频率之间均无关联。溃疡性结肠炎患者结肠环形平滑肌记录到的总和收缩频率范围更广的机制仍有待确定。
