SĂndulescu Andrei Ştefan, Stepan Alex Emilian, MĂrgĂritescu Claudiu, Badiu Anne Marie, Matei Marius, Simionescu Cristiana Eugenia
PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2020 Oct-Dec;46(4):379-382. doi: 10.12865/CHSJ.46.04.08. Epub 2020 Dec 31.
The involvement of claudins in urothelial carcinogenesis is controversial. In this study, we analyzed Claudin-4 immunoexpression in 50 cases of bladder urothelial carcinomas depending on the main prognostic parameters of the lesions represented by the tumor grade and tumor extension. Claudin-4 immunoexpression scores were significantly higher in high-grade urothelial carcinomas and in tumors with invasion in muscularis propria. The results obtained indicate the involvement of Claudin-4 in the progression of urothelial bladder carcinomas.
紧密连接蛋白在尿路上皮癌发生中的作用存在争议。在本研究中，我们根据肿瘤分级和肿瘤浸润范围所代表的病变主要预后参数，分析了50例膀胱尿路上皮癌中Claudin-4的免疫表达情况。在高级别尿路上皮癌和侵犯固有肌层的肿瘤中，Claudin-4免疫表达评分显著更高。所得结果表明Claudin-4参与了膀胱尿路上皮癌的进展。
