Takeuchi K, Ito K, Namikawa S
Research Laboratory, Fujinaga Pharmaceutical Co., Ltd., Tokyo, Japan.
Nihon Yakurigaku Zasshi. 1988 Jan;91(1):1-7. doi: 10.1254/fpj.91.1.
The anti-inflammatory effects of Glyteer (GL) were investigated by its local administration using the CMC-pouch method in rats, and the effects were compared with those of betamethasone 17-valerate (BV, 1 mg), phenylbutazone (PB, 10 mg), flufenamic acid (FA, 10 mg), bufexamac (BM, 10 and 20 mg), bendazac (BZ, 10 and 20 mg), icthammol (IT, 10 mg) and pine tar (PT, 10 mg). At three hours after CMC-treatment, GL (10 mg) significantly inhibited not only the protein exudation, but also the leucocyte migration. The inhibitory activity of GL on the leucocyte migration had the same potency as that of FA, but was stronger than those of PB, BV, BM, BZ, IT and PT. Furthermore, in relation to the leucocyte migration, GL markedly inhibited not only the neutrophil, but also the macrophage migration. At three hours after CMC-treatment, the inhibitory activity of GL on the neutrophil migration had the same potency as those of PB and FA, but was stronger than those of BV, BM, BZ, IT and PT. On the other hand, GL, BM, BZ, FA, IT and PT had an inhibitory activity on the macrophage migration, and the activity was more potent in GL, FA and IT. From these results, it is suggested that the inhibition of GL on increased vascular permeability and leucocyte migration is one of the mechanisms of its anti-inflammatory action.
采用羧甲基纤维素（CMC）袋法对大鼠进行局部给药，研究了甘醇（GL）的抗炎作用，并将其与戊酸倍他米松（BV，1毫克）、保泰松（PB，10毫克）、氟芬那酸（FA，10毫克）、丁苯羟酸（BM，10毫克和20毫克）、苄达明（BZ，10毫克和20毫克）、鱼石脂（IT，10毫克）和松焦油（PT，10毫克）的抗炎作用进行比较。在CMC处理后三小时，GL（10毫克）不仅显著抑制蛋白质渗出，还抑制白细胞迁移。GL对白细胞迁移的抑制活性与FA相同，但强于PB、BV、BM、BZ、IT和PT。此外，关于白细胞迁移，GL不仅显著抑制中性粒细胞迁移，还抑制巨噬细胞迁移。在CMC处理后三小时，GL对中性粒细胞迁移的抑制活性与PB和FA相同，但强于BV、BM、BZ、IT和PT。另一方面，GL、BM、BZ、FA、IT和PT对巨噬细胞迁移有抑制活性，其中GL、FA和IT的活性更强。从这些结果表明，GL对血管通透性增加和白细胞迁移的抑制作用是其抗炎作用机制之一。
