Kuribara H, Tadokoro S
Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, Japan.
Nihon Yakurigaku Zasshi. 1988 Feb;91(2):111-9. doi: 10.1254/fpj.91.111.
Behavioral effects of buflomedil, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride, a vasoactive drug, were investigated by means of ambulatory activity and the discrete lever-press and shuttle avoidance responses in mice. Single administration of buflomedil (1,3,10,30 and 100 mg/kg, p.o.) produced no marked change in the ambulatory activity and the discrete lever-press avoidance response. However, the ambulation-increasing effect of methamphetamine (2 mg/kg, s.c.) was suppressed by 30 mg/kg of buflomedil. The avoidance-suppressing effect of chlorpromazine (1 mg/kg, s.c.) was enhanced by 3 approximately 100 mg/kg of buflomedil, but the avoidance-suppressing effect of physostigmine (0.2 mg/kg, s.c.) was not modified by the same doses of buflomedil. On the other hand, the acquisition of the discrete shuttle avoidance response was not affected markedly by buflomedil 3, 10 and 30 mg/kg, p.o.) when the drug was administered immediately before the start of training. The present results suggest that buflomedil shows a central suppressing effect, probably through catecholaminergic neuronal systems, and that the effect is detectable only by the combined administration with typical psychoactive drugs.
血管活性药物盐酸丁咯地尔（4-(1-吡咯烷基)-1-(2,4,6-三甲氧基苯基)-1-丁酮）的行为效应通过小鼠的自主活动以及离散的杠杆按压和穿梭回避反应进行了研究。单次给予盐酸丁咯地尔（1、3、10、30和100毫克/千克，口服）对自主活动和离散的杠杆按压回避反应没有产生明显变化。然而，30毫克/千克的盐酸丁咯地尔抑制了甲基苯丙胺（2毫克/千克，皮下注射）的活动增强效应。3至100毫克/千克的盐酸丁咯地尔增强了氯丙嗪（1毫克/千克，皮下注射）的回避抑制效应，但相同剂量的盐酸丁咯地尔并未改变毒扁豆碱（0.2毫克/千克，皮下注射）的回避抑制效应。另一方面，当在训练开始前立即给予3、10和30毫克/千克（口服）的盐酸丁咯地尔时，离散穿梭回避反应的习得没有受到明显影响。目前的结果表明，盐酸丁咯地尔可能通过儿茶酚胺能神经元系统表现出中枢抑制作用，并且只有与典型的精神活性药物联合给药时才能检测到这种作用。
