Sain Arnab, Bansal Hemant, Pattabiraman Kirubakaran, Sharma Vijay
Department of Orthopaedics, JPNATC, AIIMS, New Delhi, India.
J Clin Orthop Trauma. 2021 Feb 7;17:54-58. doi: 10.1016/j.jcot.2021.01.019. eCollection 2021 Jun.
Parathyroid Hormone (PTH) has a significant role in calcium metabolism. Its intermittent administration has an anabolic effect on bone mineralization. Teriparatide (PTH 1-34), a recombinant form of parathyroid hormone, is useful in the treatment of osteoporosis, fracture healing, non-union, stress fracture, augmentation of implant fixation with bone, and chondroprotection in osteoarthritis. The present review article will elaborate on the potential approved uses of recombinant PTH in orthopedics and its evolving role in the management of fracture osteosynthesis and other common challenging bone pathologies.
甲状旁腺激素（PTH）在钙代谢中起重要作用。间歇性给药对骨矿化具有合成代谢作用。特立帕肽（PTH 1-34），一种甲状旁腺激素的重组形式，可用于治疗骨质疏松症、骨折愈合、骨不连、应力性骨折、增强植入物与骨的固定以及骨关节炎中的软骨保护。本综述文章将详细阐述重组PTH在骨科的潜在批准用途及其在骨折内固定和其他常见具有挑战性的骨病管理中的不断演变的作用。
