Illiano Ester, Trama Francesco, Mancini Vito, Ruffo Antonio, Romeo Giuseppe, Riccardo Filippo, Fabi Consuelo, Carrieri Giuseppe, Crocetto Felice, Iacono Fabrizio, Costantini Elisabetta
Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.
Urology and Kidney Transplantation Unit Ospedali Riuniti, University of Foggia, Foggia, Italy.
Transl Androl Urol. 2021 Feb;10(2):555-562. doi: 10.21037/tau-20-1067.
Peyonie's disease (PD) mostly affects males in the fifth decade of life, with a prevalence in the general population ranging between 0.5% and 20.3%. The pathology of PD is characterized by fibrosis of the tunic albuginea of the cavernous bodies of the penis, with the presence of pain in the erection and penile deformity. This is associated with decreased sexual function for both participants. The objective of the study was to investigate the influence of PD pathology on both male patients' and their female partners' sexual spheres, and analyze changes in sexual function and perception following penile correction surgery.
Prospective study, we included male patients with PD and their female partner sexually active. Patients underwent corporoplasty with multiple plications. The male and female sexuality was evaluated before surgery and three months after male treatment by the Female sexual Function Index (FSFI); International Index of Erectile Function (IIEF); Visual Analogical Scale (VAS).
From January 2018 to November 2019 we included 35 couple. The female subjects before partner's surgery presented dyspareunia, loss of sexual desire, inability to achieve orgasm, and sexual dissatisfaction. At three months after surgical treatment there was an improvement of sexual function in both male patients and female partners (desire P<0.0001, arousal P<0.0001, lubrification P<0.0001, orgasm P<0.0001, satisfaction P<0.0001, pain P<0.0001). As regarding male patients the pain decreased significantly (VAS score from 6 to 2.5), while there was no statistically significant improvement in erectile function (P=0.05).
Our findings suggest that a viable approach to treatment of PD patients that involves their partners could lead to better functional and psychological results.
佩罗尼氏病（PD）主要影响50岁左右的男性，在普通人群中的患病率在0.5%至20.3%之间。PD的病理学特征是阴茎海绵体白膜纤维化，伴有勃起疼痛和阴茎畸形。这与双方性功能下降有关。本研究的目的是调查PD病理学对男性患者及其女性伴侣性领域的影响，并分析阴茎矫正手术后性功能和认知的变化。
前瞻性研究，我们纳入了患有PD且有性活动的男性患者及其女性伴侣。患者接受了多次折叠的阴茎成形术。通过女性性功能指数（FSFI）、国际勃起功能指数（IIEF）、视觉模拟量表（VAS）在手术前和男性治疗后三个月对男性和女性的性功能进行评估。
从2018年1月至2019年11月，我们纳入了35对夫妇。女性受试者在伴侣手术前出现性交困难、性欲减退、无法达到性高潮和性不满。手术治疗三个月后，男性患者和女性伴侣的性功能均有改善（欲望P<0.0001，唤起P<0.0001，润滑P<0.0001，性高潮P<0.0001，满意度P<0.0001，疼痛P<0.0001）。对于男性患者，疼痛明显减轻（VAS评分从6降至2.5），而勃起功能无统计学显著改善（P=0.05）。
我们的研究结果表明，一种涉及患者伴侣的可行的PD治疗方法可能会带来更好的功能和心理结果。
