格子状角膜营养不良穿透性角膜移植术后的神经营养性角膜炎。
Neurotrophic keratitis after penetrating keratoplasty for lattice dystrophy.
作者信息
Gouvea Larissa, Penatti Raphael, Rocha Karolinne Maia
机构信息
Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.
Waring Vision Institute, Charleston, SC, USA.
出版信息
Am J Ophthalmol Case Rep. 2021 Feb 26;22:101058. doi: 10.1016/j.ajoc.2021.101058. eCollection 2021 Jun.
PURPOSE
To report clinical outcomes of a patient with unilateral neurotrophic keratitis following penetrating keratoplasty for lattice dystrophy treated with topical recombinant human nerve growth factor.
OBSERVATIONS
A 75-year-old male with lattice dystrophy and history of herpes simplex keratitis, presented with recurrent neurotrophic ulceration in the right eye two years following penetrating keratoplasty. The patient was successfully treated with topical recombinant human nerve growth factor.
CONCLUSION
Neurotrophic keratitis is a rare chronic disorder that affects quality of life due to the risk of vision loss. Topical recombinant human nerve growth factor is a novel and effective treatment option that may help improve optical quality and patient's satisfaction as shown in this case of recurrent neurotrophic keratitis.
目的
报告一名患有格子状角膜营养不良的患者在穿透性角膜移植术后发生单侧神经营养性角膜炎，经局部应用重组人神经生长因子治疗后的临床结果。
观察结果
一名75岁男性，有格子状角膜营养不良病史及单纯疱疹性角膜炎病史，在穿透性角膜移植术后两年出现右眼复发性神经营养性溃疡。该患者经局部应用重组人神经生长因子治疗成功。
结论
神经营养性角膜炎是一种罕见的慢性疾病，因存在视力丧失风险而影响生活质量。局部应用重组人神经生长因子是一种新型有效的治疗选择，如本复发性神经营养性角膜炎病例所示，可能有助于改善光学质量和患者满意度。
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