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糖尿病和高血压会增加新型冠状病毒患者的死亡风险,与年龄无关:一项来自印度的关于合并症与COVID-19的前瞻性观察研究。

Diabetes Mellitus and Hypertension Increase Risk of Death in Novel Corona Virus Patients Irrespective of Age: a Prospective Observational Study of Co-morbidities and COVID-19 from India.

作者信息

Gupta Anirban, Nayan Neelabh, Nair Ranjith, Kumar Krishna, Joshi Aditya, Sharma Shivangi, Singh Jasdeep, Kapoor Rajan

机构信息

Department of Internal Medicine, Command Hospital (Eastern Command), Kolkata, 700027 India.

Department of Anaesthesia and Critical Care, Command Hospital (Eastern Command), Kolkata, India.

出版信息

SN Compr Clin Med. 2021;3(4):937-944. doi: 10.1007/s42399-021-00851-1. Epub 2021 Mar 8.

Abstract

Elderly people and people with co-morbidities have emerged as the most vulnerable group at risk of developing complications and succumbing to novel coronavirus (COVID-19) infection. We recorded the baseline demographic profile, baseline clinical and laboratory parameters, and prevalence of various co-morbidities and their effect on the prognosis of COVID-19 cases. We conducted a prospective observational study and analyzed baseline clinical and laboratory parameters and co-morbidities and their effect on severity and mortality in 710 COVID-19 cases. Seven hundred ten patients with laboratory-confirmed COVID-19 were recruited from the 28 of March to the 31 of August 2020. The mean age was 48.4 ± 16.4years. A total of 530 (74.6%) patients were male. Overall, the mean length of hospital stay was 12.7 days. In total, 645 patients(90.8%) were mild to moderate cases and did not require initial ICU care. Sixty-five (9.2%) cases required initial intensive care unit care. Fifty (7%) admitted patients succumbed to the illness. Diabetes mellitus and hypertension increased the risk of death in COVID-19 patients irrespective of age. Increasing age and co-morbidities adversely affect the prognosis of patients of COVID-19. Diabetes mellitus and hypertension increase the risk of death in COVID-19 patients and negate the incremental effect of age on death in these patients.

摘要

老年人和患有合并症的人已成为最易感染新型冠状病毒(COVID-19)并出现并发症甚至死亡的脆弱群体。我们记录了基线人口统计学特征、基线临床和实验室参数、各种合并症的患病率及其对COVID-19病例预后的影响。我们进行了一项前瞻性观察性研究,分析了710例COVID-19病例的基线临床和实验室参数、合并症及其对严重程度和死亡率的影响。2020年3月28日至8月31日期间招募了710例实验室确诊的COVID-19患者。平均年龄为48.4±16.4岁。共有530名(74.6%)患者为男性。总体而言,平均住院时间为12.7天。总共有645名患者(90.8%)为轻症至中症病例,无需初始重症监护。65例(9.2%)病例需要初始重症监护病房护理。50例(7%)入院患者因病死亡。无论年龄大小,糖尿病和高血压都会增加COVID-19患者的死亡风险。年龄增长和合并症会对COVID-19患者的预后产生不利影响。糖尿病和高血压会增加COVID-19患者的死亡风险,并抵消年龄对这些患者死亡的增量影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddcd/7939447/543ec068a804/42399_2021_851_Fig1_HTML.jpg

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