Yasumizu Yota, Kosaka Takeo, Hongo Hiroshi, Mizuno Ryuichi, Oya Mototsugu
Department of Urology Keio University School of Medicine Tokyo Japan.
IJU Case Rep. 2021 Jan 21;4(2):108-111. doi: 10.1002/iju5.12255. eCollection 2021 Mar.
Skull base metastasis of prostate cancer associated with cranial nerve palsy is rare. We observed three patients with aggressive prostate cancer who experienced cranial nerve palsy.
Case 1 was a 53-year-old patient who was treated with carboplatin and etoposide. He noticed sensory abnormalities on his left mouth edge. Head magnetic resonance imaging revealed skull base metastasis. Case 2 was a 50-year-old patient who received docetaxel. This patient exhibited ptosis of the left eye. Skull base metastasis was detected by magnetic resonance imaging. External beam radiation therapy was performed. Case 3 was a 64-year-old patient who was treated with docetaxel. He experienced ptosis of the right eye and diplopia. He was also treated with external beam radiation therapy.
External beam radiation therapy exhibited some efficacy against the symptoms, but skull base metastasis of treatment-resistant prostate cancer has poor prognosis. Three patients died within 3 months after symptoms occurred with or without external beam radiation therapy.
前列腺癌颅底转移伴脑神经麻痹较为罕见。我们观察到3例侵袭性前列腺癌患者出现了脑神经麻痹。
病例1为一名53岁患者，接受了卡铂和依托泊苷治疗。他注意到左口角有感觉异常。头部磁共振成像显示颅底转移。病例2为一名50岁患者，接受了多西他赛治疗。该患者出现左眼上睑下垂。磁共振成像检测到颅底转移。进行了外照射放疗。病例3为一名64岁患者，接受了多西他赛治疗。他出现右眼上睑下垂和复视。他也接受了外照射放疗。
外照射放疗对症状有一定疗效，但难治性前列腺癌颅底转移预后较差。3例患者在出现症状后3个月内死亡，无论是否接受外照射放疗。
