Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Clin Chem. 2021 Jun 1;67(6):820-822. doi: 10.1093/clinchem/hvab029.
The Kidney Disease Improving Global Outcomes 2012 Clinical Practice Guideline on Chronic Kidney Disease (1) recommends calculating estimated glomerular filtration rate (eGFR) using equations developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) for adults ≥18 years (2) and by the Chronic Kidney Disease in Children (CKiD) for ages <18 years (3). These equations were recommended because they used readily available information, serum/plasma/blood creatinine, plus age, sex, and race for adults, and height for children; and have been validated in large and diverse cohorts of people who had measured glomerular filtration rate (mGFR) as a basis for establishing accuracy.
肾脏疾病改善全球结果组织 2012 年慢性肾脏病临床实践指南(1)建议使用慢性肾脏病流行病学合作组(CKD-EPI)为成年人(2)和儿童慢性肾脏病(CKiD)为年龄<18 岁的儿童(3)开发的公式来计算估算肾小球滤过率(eGFR)。这些公式之所以被推荐,是因为它们使用了易于获得的信息,如血清/血浆/血液肌酐,加上成年人的年龄、性别和种族,以及儿童的身高;并且已经在大量不同人群中进行了验证,这些人群的肾小球滤过率(mGFR)是作为准确性基础的。