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Baerveldt 青光眼植入物巩膜下固定手术的 3 年疗效。

Three-year outcome of sulcus fixation of Baerveldt glaucoma implant surgery.

机构信息

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.

出版信息

Acta Ophthalmol. 2021 Dec;99(8):e1435-e1441. doi: 10.1111/aos.14839. Epub 2021 Mar 15.

Abstract

PURPOSE

The purpose of this study was to evaluate the 3-year surgical outcome of the sulcus fixation of Baerveldt glaucoma implant (BGI), focusing on corneal damage.

METHODS

This prospective observational study included 37 patients who underwent a median of two previous glaucoma surgeries and sulcus fixation of BGI for the first time. Each patient's intraocular pressure (IOP), glaucoma drug score, corneal endothelial cell density (ECD), and logMAR-converted best-corrected visual acuity (VA) were measured preoperatively and postoperatively until 36 months after surgery. Complete success was defined as reduced IOP (5-21 mmHg and >20% rate), without corneal damage (postoperative development of decompensation, unmeasurable ECD, or reduction in ECD of >20%), without loss of light perception, and without additional surgery requirement. Qualified success was defined by excluding the corneal criteria from complete success.

RESULTS

A total of 51% (19/37) patients experienced complete treatment success, whereas 86% (32/37) had qualified success. The median IOP (glaucoma drug score) decreased from 26 mmHg (5) to 15 mmHg (2) at three years postoperatively. The median postoperative ECD (reduction rate) decreased from 1838 cells/cm preoperatively to 1587 cells/mm (14%) at one year, 1358 cells/mm (26%) at two years, and 1228 cells/mm (33%) at three years postoperatively. One month after surgery, the VA was significantly reduced from preoperative values but did not decline after that.

CONCLUSION

Sulcus fixation of BGI was effective for IOP reduction. However, ECD decreased over time.

摘要

目的

本研究旨在评估 Baerveldt 青光眼植入物(BGI)巩膜固定术的 3 年手术效果,重点关注角膜损伤。

方法

这是一项前瞻性观察研究,共纳入 37 例患者,这些患者均接受过中位数为 2 次的先前青光眼手术,且首次行 BGI 巩膜固定术。每位患者的眼内压(IOP)、青光眼药物评分、角膜内皮细胞密度(ECD)和对数视力矫正最佳视力(VA)在术前和术后测量,直至术后 36 个月。完全成功定义为 IOP 降低(5-21mmHg,降低率>20%),无角膜损伤(术后出现失代偿、无法测量 ECD 或 ECD 降低>20%)、无光感丧失,且无需额外手术。合格成功定义为从完全成功中排除角膜标准。

结果

共有 51%(19/37)的患者获得完全治疗成功,86%(32/37)的患者获得合格成功。术后 3 年时,IOP(青光眼药物评分)中位数从 26mmHg(5)降低至 15mmHg(2)。术后 ECD 中位数(降低率)从术前的 1838 个细胞/cm 降低至 1 年后的 1587 个细胞/mm(14%)、2 年后的 1358 个细胞/mm(26%)和 3 年后的 1228 个细胞/mm(33%)。术后 1 个月时,VA 显著低于术前,但此后未再下降。

结论

BGI 巩膜固定术可有效降低 IOP,但 ECD 随时间逐渐降低。

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