Mironova O I, Deev A D, Lakotka P G, Fomin V V
Sechenov First Moscow State Medical University (Sechenov University).
National Research Center for Therapy and Preventive Medicine.
Ter Arkh. 2020 Dec 15;92(12):48-52. doi: 10.26442/00403660.2020.12.200450.
The aim of our study was to assess the role of anemia as a risk factor of contrast-associated acute kidney injury (CA-AKI) in patients with stable coronary artery disease.
1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). 83 patients had anemia. CA-AKI was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The primary endpoint of the study was the development of CA-AKI according to KDIGO criteria.
CA-AKI developed in 12 (14.5%) patients with anemia according to the relative increase of the level of serum creatinine (25% and more from the baseline). With using the absolute increase of the level of serum creatinine the prevalence of CA-AKI was 2 (2.4%) patients. Patients with anemia had higher rate of CA-AKI than the overall population of the study (14.4% versus 12.7%). Although our results were not statistically significant (р=0.61, odds ratio 1.19, 95% confidence interval 0.632.24).
The prevalence of CA-AKI was higher in the group of patients with anemia, but didnt meet statistical significance and needs further evaluation in larger studies.
我们研究的目的是评估贫血作为稳定型冠状动脉疾病患者对比剂相关急性肾损伤（CA-AKI）危险因素的作用。
1023例慢性冠状动脉疾病患者被纳入一项前瞻性、开放性队列研究（ClinicalTrials.gov标识符NCT04014153）。83例患者患有贫血。CA-AKI定义为在注射对比剂后48小时评估时，血清肌酐较基线值升高25%或更多，或绝对升高0.5mg/dl或更多。该研究的主要终点是根据KDIGO标准发生的CA-AKI。
根据血清肌酐水平的相对升高（较基线升高25%及以上），12例（14.5%）贫血患者发生了CA-AKI。按照血清肌酐水平的绝对升高计算，CA-AKI的患病率为2例（2.4%）。贫血患者的CA-AKI发生率高于研究的总体人群（14.4%对12.7%）。尽管我们的结果无统计学意义（p = 0.61，比值比1.19，95%置信区间0.63 - 2.24）。
贫血患者组中CA-AKI的患病率较高，但未达到统计学意义，需要在更大规模的研究中进一步评估。
