Popova O P, Smetanina S V, Antipyat N A, Revazyan N R, Skirda T A
Russian Medical Academy of Continuous Professional Education.
Infectious Clinical Hospital №1.
Ter Arkh. 2020 Dec 26;92(11):13-16. doi: 10.26442/00403660.2020.11.000417.
To study the clinical course, diagnosis of pertussis in pregnant women.
Under observation were 25 pregnant women with whooping cough. The age structure was dominated by patients from 6 to 35 years old, amounting to 64%. At the time of hospitalization in 2 (8%) patients the gestation period corresponded to the first trimester, in 7 (28%) II, in 9 (36%) III. In 7 (28%) patients, the diagnosis of whooping cough was made during childbirth. The following methods were used to verify pertussis: bacteriological, PCR and serological (ELISA).
Clinical analysis showed that pregnant women with pertussis who came to the hospital were admitted to hospital mainly in the late stages of the disease (at 45 week in 68.6% of cases). Pertussis infection in all cases was typical: in moderate form 96%, mild at 4%. In 64% of patients, whooping cough accompanied by other respiratory diseases, which were the main cause of development of bronchitis. The use of ELISA allowed to confirm the clinical diagnosis in 91.7% of patients.
The course of whooping cough in pregnant women is characterized by a typical symptom complex. To improve the verification of the diagnosis, it is advisable to use modern laboratory tests (PCR, ELISA).
研究孕妇百日咳的临床病程及诊断。
观察了25例患百日咳的孕妇。年龄结构以6至35岁的患者为主,占64%。住院时,2例(8%)患者的妊娠期处于孕早期,7例(28%)处于孕中期,9例(36%)处于孕晚期。7例(28%)患者在分娩时被诊断为百日咳。采用以下方法确诊百日咳:细菌学、聚合酶链反应(PCR)和血清学(酶联免疫吸附测定法,ELISA)。
临床分析表明,前来医院就诊的患百日咳孕妇主要在疾病晚期入院(68.6%的病例在4至5周)。所有病例的百日咳感染均为典型:中度形式占96%,轻度占4%。64%的患者百日咳伴有其他呼吸道疾病,这些是支气管炎发展的主要原因。使用酶联免疫吸附测定法可在91.7%的患者中确诊临床诊断。
孕妇百日咳病程具有典型的症状组合。为提高诊断的确诊率,建议使用现代实验室检测方法(PCR、酶联免疫吸附测定法)。