Hausdorf G, Rieger U, Koepp P
University of Hamburg, Childrens Hospital, F.R.G.
Int J Cardiol. 1988 May;19(2):225-36. doi: 10.1016/0167-5273(88)90083-6.
Cardiac function was evaluated using computer-assisted analysis of M-mode echocardiograms in 36 patients with onset of type I diabetes (insulin-dependent diabetes) in childhood. None of the patients had clinical evidence for cardiovascular disease or microvascular disease. An impairment of diastolic function was observed in the older patients with long-standing diabetes. The time between minimal cavity dimension and mitral valve opening was significantly prolonged (P less than 0.005), while the change of dimension in this time period and the change of dimension with rapid diastolic filling were normal. Although fractional shortening as a parameter of systolic function was normal in the diabetics, fractional shortening was inversely related to the mean HbA1 averaged over the last two years, reflecting the status of long-term metabolic control (P less than 0.0008). The time between minimum cavity dimension and mitral opening was also related to the mean HbA1 averaged over the last two years (P less than 0.0011). It is concluded that, with time, alterations of both systolic and diastolic function develop in children with type I diabetes. Their severity depends on the quality of metabolic control.
采用计算机辅助分析M型超声心动图对36例儿童期发病的Ⅰ型糖尿病（胰岛素依赖型糖尿病）患者的心脏功能进行了评估。所有患者均无心血管疾病或微血管疾病的临床证据。在病程较长的老年糖尿病患者中观察到舒张功能受损。最小腔径与二尖瓣开放之间的时间显著延长（P<0.005），而在此时间段内的腔径变化以及快速舒张期充盈时的腔径变化均正常。虽然作为收缩功能参数的缩短分数在糖尿病患者中正常，但缩短分数与过去两年的平均糖化血红蛋白呈负相关，反映了长期代谢控制状况（P<0.0008）。最小腔径与二尖瓣开放之间的时间也与过去两年的平均糖化血红蛋白有关（P<0.0011）。结论是，随着时间推移，Ⅰ型糖尿病儿童会出现收缩和舒张功能的改变。其严重程度取决于代谢控制的质量。
