Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
J Neonatal Perinatal Med. 2021;14(4):519-526. doi: 10.3233/NPM-200637.
The optimal oxygen saturation target in preterm infants is not known. In this study, we aimed to assess the effect of lower oxygen saturation targets on the rate of bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and pulmonary hypertension (PH) in preterm infants.
Retrospective cohort study comparing BPD, ROP, and PH incidence among two cohorts of infants born at≤32 weeks gestation with different oxygen saturation targets at≥34 weeks post-menstrual age (PMA): cohort 1, 94-98% (n = 126); cohort 2, 92-97% (n = 121). Groups compared by Chi-square test, t-test, and multivariable logistic regression.
When comparing cohort 1 (average gestational age 29.8 weeks, average birth weight 1271g) with cohort 2 (average gestational age 29.6 weeks, average birth weight 1299g), there was no difference in rate of BPD (24% vs. 19%, p = 0.38), ROP (4% vs. 3%, p = 0.49), or PH (2% vs. 4%, p = 0.44).
An oxygen saturation target of 92-97% at≥34 weeks PMA was not associated with a higher rate of PH or lower rate of BPD or ROP when compared with a higher target of 94-98%.
早产儿的最佳氧饱和度目标尚不清楚。本研究旨在评估较低的氧饱和度目标对早产儿支气管肺发育不良（BPD）、早产儿视网膜病变（ROP）和肺动脉高压（PH）发生率的影响。
回顾性队列研究比较了胎龄≤32 周、出生后≥34 周校正胎龄（PMA）时氧饱和度目标不同的两组婴儿的 BPD、ROP 和 PH 发生率：第 1 组，94-98%（n=126）；第 2 组，92-97%（n=121）。使用卡方检验、t 检验和多变量逻辑回归比较两组。
第 1 组（平均胎龄 29.8 周，平均出生体重 1271g）与第 2 组（平均胎龄 29.6 周，平均出生体重 1299g）比较，BPD 发生率（24%比 19%，p=0.38）、ROP（4%比 3%，p=0.49）或 PH（2%比 4%，p=0.44）无差异。
与较高的目标值 94-98%相比，在≥34 周 PMA 时将氧饱和度目标设定为 92-97%与 PH 发生率较高或 BPD 或 ROP 发生率较低无关。
