Maslow D E, Goldrosen M H
Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, N.Y.
Invasion Metastasis. 1988;8(3):133-42.
Cell motility is an important factor in the metastatic process that can be affected by environmental conditions. A quantitative study was made of the relationship between cell motility and the colonization potential of a mouse colon adenocarcinoma cell line (MCA-38). MCA-38 cells grown in culture did not produce hepatic or pulmonary colonies following ileocolic or tail vein injection, respectively. In contrast, MCA-38 cells adapted to grow in the mouse produced colonies in both organs. The motility of the MCA-38 cells that did not produce colonies, as determined by the depth of penetration into cellulose nitrate filters (8 micron pore size), was significantly less than that of MCA-38 cells with colony-forming potential. Return to in vitro growth resulted in both a loss of colonization potential and a reduction in motility. In this system, secondary organ colonization and in vitro cell motility are positively correlated, suggesting an association between cell motility and metastatic potential.
细胞运动性是转移过程中的一个重要因素，它会受到环境条件的影响。对小鼠结肠腺癌细胞系（MCA - 38）的细胞运动性与定植潜能之间的关系进行了定量研究。在培养中生长的MCA - 38细胞分别经回结肠或尾静脉注射后，未产生肝或肺菌落。相比之下，适应在小鼠体内生长的MCA - 38细胞在两个器官中均产生了菌落。通过穿透硝酸纤维素滤膜（孔径8微米）的深度测定，未产生菌落的MCA - 38细胞的运动性明显低于具有集落形成潜能的MCA - 38细胞。恢复体外生长导致定植潜能丧失和运动性降低。在这个系统中，次级器官定植与体外细胞运动性呈正相关，表明细胞运动性与转移潜能之间存在关联。
