Sleep Research & Treatment Center, Penn State Health Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, USA.
University of Arizona, College of Education, USA.
Sleep Med. 2021 May;81:235-243. doi: 10.1016/j.sleep.2021.02.033. Epub 2021 Feb 23.
Traits related to a hyper-reactive arousal system (arousability) and weakened sleep system (sleep reactivity) are considered predisposing factors for insomnia of potential clinical utility. However, research examining the psychometric properties (ie, reliability and validity) of the Arousal Predisposition Scale (APS) and its clinical utility (ie, cut-off scores) among population-based and clinical samples is very limited.
A total of 500 adults (41.8% female, 39.1 ± 15.9 years) from the general population in Spain and 217 adults (64.5% female, 46.0 ± 16.1 years) from a clinical sample in the United States completed the APS, as well as measures of sleep reactivity, insomnia severity, anxiety, depression, and stress. Structural equation modeling was used to conduct confirmatory factor analysis (CFA) of the APS. Correlation and receiver operating characteristic (ROC) analyses were used to determine convergent and predictive validity of the APS and its factors.
The CFAs supported two dimensions of emotional reactivity (APS-ER, 9 items) and trait anxiety (APS-TA, 3 items) in both independent samples. APS-ER was associated with sleep reactivity and performed better than APS-TA when predicting clinically significant sleep reactivity and similarly when predicting clinically significant insomnia severity.
Our findings support the specificity of emotional reactivity and sleep reactivity as trait predispositions to insomnia, while trait anxiety is a predisposing factor for the comorbidity of insomnia with state anxiety rather than a specific diathesis for insomnia. These data provide further support for the diathesis-stress model of insomnia and, as a transdiagnostic process, its potential etiological link with psychopathology.
与高度活跃的觉醒系统(觉醒性)和减弱的睡眠系统(睡眠反应性)相关的特征被认为是失眠的潜在临床有用的易感因素。然而,研究觉醒倾向量表(APS)的心理测量特性(即可靠性和有效性)及其在基于人群和临床样本中的临床实用性(即临界值分数)的研究非常有限。
共有 500 名来自西班牙普通人群的成年人(41.8%为女性,39.1±15.9 岁)和 217 名来自美国临床样本的成年人(64.5%为女性,46.0±16.1 岁)完成了 APS 以及睡眠反应性、失眠严重程度、焦虑、抑郁和压力的测量。使用结构方程模型对 APS 进行验证性因素分析(CFA)。相关性和接收者操作特征(ROC)分析用于确定 APS 及其因子的收敛和预测有效性。
在两个独立样本中,CFA 均支持情绪反应(APS-ER,9 项)和特质焦虑(APS-TA,3 项)两个维度。APS-ER 与睡眠反应性相关,在预测临床显著的睡眠反应性方面优于 APS-TA,在预测临床显著的失眠严重程度方面表现类似。
我们的研究结果支持情绪反应和睡眠反应性作为失眠易感性的特质特异性,而特质焦虑是失眠与状态焦虑共病的易感因素,而不是失眠的特定素质。这些数据为失眠的素质-应激模型提供了进一步的支持,并且作为一种跨诊断过程,它可能与精神病理学存在病因学联系。