韩国人群中 RTN4 基因启动子单倍型与精神分裂症的关联。
Association between the promoter haplotype of RTN4 gene and schizophrenia in a Korean population.
机构信息
Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Department of Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
出版信息
Psychiatry Res. 2021 May;299:113841. doi: 10.1016/j.psychres.2021.113841. Epub 2021 Mar 2.
Previous studies have suggested the involvement of Nogo-A/RTN4 in the pathogenesis of schizophrenia. We investigated an association between the promoter haplotypes of RTN4 comprised of rs1348528-rs1822618-rs2241958 and schizophrenia. A significant association between the rare TGA haplotype and schizophrenia was shown (p < 0.0001). Additionally, the promoter activity was profoundly decreased by the TGA haplotype. These results suggested that the TGA haplotype of RTN4 may contribute to the susceptibility of schizophrenia.
先前的研究表明 Nogo-A/RTN4 参与了精神分裂症的发病机制。我们研究了由 rs1348528-rs1822618-rs2241958 组成的 RTN4 启动子单倍型与精神分裂症之间的关联。罕见的 TGA 单倍型与精神分裂症之间存在显著关联（p<0.0001）。此外，TGA 单倍型显著降低了启动子活性。这些结果表明，RTN4 的 TGA 单倍型可能导致精神分裂症的易感性。
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