[他莫昔芬引起的眼部毒性：综述]

[Ocular toxicity induced by tamoxifen: an overview].

作者信息

Wang M, Ma J, Zhong Y

机构信息

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100730, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2021 Mar 11;57(3):232-236. doi: 10.3760/cma.j.cn112142-20200324-00221.

DOI:10.3760/cma.j.cn112142-20200324-00221

PMID:33721964

Abstract

By reviewing the recent articles regarding the ocular side effect of tamoxifen when treating breast cancer and glioma, this article summarized the incidence and the potential mechanism of the side effects of tamoxifen, and the specific ocular toxicity including keratopathy, cataract, retinopathy, optic neuropathy. This review would provide guidance for clinical ophthalmologists to early identify and appropriately manage tamoxifen induced ocular diseases. .

摘要

通过回顾近期关于他莫昔芬治疗乳腺癌和胶质瘤时眼部副作用的文章，本文总结了他莫昔芬副作用的发生率和潜在机制，以及包括角膜病变、白内障、视网膜病变、视神经病变在内的具体眼部毒性。本综述将为临床眼科医生早期识别和妥善处理他莫昔芬所致眼部疾病提供指导。