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Mutations in the HIV-1 3'-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance.

作者信息

Wei Yuliang, Sluis-Cremer Nicolas

机构信息

Tsinghua MD Program, School of Medicine, Tsinghua University, Beijing, China.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

出版信息

Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02432-20.

DOI:10.1128/AAC.02432-20
PMID:33722887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8316055/
Abstract
摘要

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本文引用的文献

1
Variability of the HIV-1 3' polypurine tract (3'PPT) region and implication in integrase inhibitor resistance.HIV-1 3' 多聚嘧啶区（3'PPT）的变异性及其对整合酶抑制剂耐药性的影响。
J Antimicrob Chemother. 2019 Dec 1;74(12):3440-3444. doi: 10.1093/jac/dkz377.
2
HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy.多替拉韦维持治疗失败的患者中 HIV-1 耐药性的动态变化。
J Infect Dis. 2018 Jul 24;218(5):688-697. doi: 10.1093/infdis/jiy176.
3
Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors.突变位于整合酶基因之外可赋予 HIV-1 整合酶链转移抑制剂耐药性。
mBio. 2017 Sep 26;8(5):e00922-17. doi: 10.1128/mBio.00922-17.
4
HIV drug resistance against strand transfer integrase inhibitors.HIV 对链转移整合酶抑制剂的耐药性。
Retrovirology. 2017 Jun 5;14(1):36. doi: 10.1186/s12977-017-0360-7.
5
Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection.利匹韦林、达匹韦林和MIV-150的交叉耐药性概况，这三种处于临床开发阶段用于预防HIV-1感染的非核苷类逆转录酶抑制剂杀菌剂。
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00277-17. Print 2017 Jul.
6
Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.HIV-1逆转录酶连接子域突变对多聚嘌呤序列去除及正链DNA合成起始的影响。
Nucleic Acids Res. 2015 Feb 27;43(4):2259-70. doi: 10.1093/nar/gkv077. Epub 2015 Feb 6.
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Improved single-copy assays for quantification of persistent HIV-1 viremia in patients on suppressive antiretroviral therapy.改良的单拷贝检测法用于定量检测接受抑制性抗逆转录病毒治疗的患者体内持续性 HIV-1 病毒血症。
J Clin Microbiol. 2014 Nov;52(11):3944-51. doi: 10.1128/JCM.02060-14. Epub 2014 Sep 3.
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N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.HIV-1 逆转录酶中的 N348I 可以抵抗奈韦拉平在正链起始过程中引起的 RNase H 切割偏向。
J Biol Chem. 2010 Aug 27;285(35):26966-26975. doi: 10.1074/jbc.M110.105775. Epub 2010 Jun 8.
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HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro.HIV-1逆转录酶正链起始在体外对非核苷类逆转录酶抑制剂表现出优先敏感性。
J Biol Chem. 2007 Mar 16;282(11):8005-10. doi: 10.1074/jbc.M608274200. Epub 2006 Dec 15.