Shaker E, Hurvitz A I, Peterson M E
Department of Medicine, Animal Medical Center, New York, NY 10021.
J Am Vet Med Assoc. 1988 Apr 15;192(8):1091-2.
Thirty-one ancestors of a Standard Poodle with hypoadrenocorticism were located. Hypoadrenocorticism had been confirmed in 8 of 32 dogs (25%) by use of ACTH response testing or necropsy. In 2 additional dogs, hypoadrenocorticism was diagnosed on the basis of characteristic clinical signs and serum electrolyte abnormalities consistent with adrenocortical insufficiency. Although an obvious pattern of inheritance was not evident, the high prevalence of hypoadrenocorticism suggested that heredity may have been a factor in the development of idiopathic adrenal insufficiency in dogs of this family.
找到了31只患有肾上腺皮质功能减退症的标准贵宾犬的祖先。通过促肾上腺皮质激素反应测试或尸检，在32只犬中有8只（25%）被确诊患有肾上腺皮质功能减退症。另外2只犬，根据与肾上腺皮质功能不全相符的特征性临床症状和血清电解质异常被诊断为肾上腺皮质功能减退症。尽管没有明显的遗传模式，但肾上腺皮质功能减退症的高患病率表明，遗传可能是这个家族犬特发性肾上腺功能不全发病的一个因素。
