人类基因组的核苷酸间距分布分析

Nucleotide spacing distribution analysis for human genome.

作者信息

Górski Andrzej Z, Piwowar Monika

机构信息

Polish Academy of Sciences, Institute of Nuclear Physics, Radzikowskiego 152 st, 31-342, Kraków, Poland.

Jagiellonian University, Collegium Medicum, Kopernika 7E st, 31-034, Kraków, Poland.

出版信息

Mamm Genome. 2021 Apr;32(2):123-128. doi: 10.1007/s00335-021-09865-5. Epub 2021 Mar 15.

DOI:10.1007/s00335-021-09865-5

PMID:33723659

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8012312/

Abstract

The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results nevertheless revealed several characteristic features: (i) the distribution for short-range spacing is quite similar to the purely stochastic sequences; (ii) the distribution for long-range spacing essentially deviates from the random sequence distribution, showing strong long-range correlations; (iii) the differences between (A, T) and (C, G) nucleotides are quite significant; (iv) the spacing distribution displays tiny oscillations.

摘要

对人类基因组中核苷酸间距的分布进行了研究。对人类基因组中由一种核苷酸侧翼的不同序列长度的出现频率进行了分析，结果表明该分布没有自相似（分形）结构。然而，结果揭示了几个特征：（i）短程间距的分布与纯随机序列非常相似；（ii）长程间距的分布基本上偏离随机序列分布，显示出强烈的长程相关性；（iii）（A，T）和（C，G）核苷酸之间的差异相当显著；（iv）间距分布显示出微小的振荡。