Bone and joint infections caused by Clostridium perfringens: a case series.
作者信息
Visse Margaux, Vernet-Garnier Véronique, Bajolet Odile, Lebrun Delphine, Bonnet Morgane, Hentzien Maxime, Ohl Xavier, Diallo Saidou, Bani-Sadr Firouzé
机构信息
Department of Internal Medicine and Infectious Diseases, Reims Teaching Hospitals, Avenue du Général Koenig, 51092, Reims, France.
Department of Bacteriology, Reims Teaching Hospitals, Reims, France.
出版信息
Eur J Clin Microbiol Infect Dis. 2021 Oct;40(10):2221-2225. doi: 10.1007/s10096-021-04225-2. Epub 2021 Mar 16.
The objective of this study was to evaluate antimicrobial therapy outcomes of bone and joint infections (BJI) caused by Clostridium perfringens. We investigated remission of symptoms and the absence of relapse or reinfection during follow-up. Among the 8 patients with C. perfringens BJI, the type of infection was early prosthesis infection (n = 2), osteosynthetic device infection (n = 4), and chronic osteomyeletis (n = 2). Clindamycin-rifampicin combination was given in 4 cases and metronidazole in 4 cases. The overall success rate was 87.5%. Among the 7 patients who completed antibiotic treatment, the success rate was 100%. The clindamycin-rifampicin combination appeared to be effective in patients with C. perfringens BJI.
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