Department of Otorhinolaryngology, University Hospital Heidelberg, Heidelberg, Germany.
Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany.
Clin Otolaryngol. 2021 Sep;46(5):948-953. doi: 10.1111/coa.13753. Epub 2021 Mar 22.
To evaluate the rate of surgical site infection (SSI) and associated risk factors after parotid gland surgery including the impact of antibiotic prophylaxis.
Retrospective single-centre clinical study.
Tertiary referral centre for head and neck surgery.
Seven hundred and fifty four patients who underwent parotid gland surgery at the University Hospital Heidelberg, Germany, between 2007 and 2014 were enrolled in this study. Data on patient age, American Society of Anesthesiologists (ASA) classification system, smoking status, diabetes mellitus, operation time, and antibiotic prophylaxis were collected. Additionally, the National Healthcare Safety Network (NHSN) risk index was calculated. Association of these factors with SSI was evaluated in univariate analyses and a multivariate logistic regression model.
Rate of SSI.
Twenty four patients (3.2%) had an SSI according to the NHSN definition. In univariate analyses, only smokers (P = .048) and male patients (P = .01) had a significantly higher rate of SSI. Since the majority of smokers were men (62.3%), the effect of male gender, smoking, together with the NHSN risk index was further investigated as predictors of SSI within a logistic regression model. All three predictors showed a significant effect on SSI.
Parotid gland surgery has a low rate of SSI. In our cohort, male gender, smoking and high NHSN risk index scores were significantly associated with SSI, whereas antibiotic prophylaxis had no protective effect.
评估腮腺手术后手术部位感染（SSI）的发生率及相关危险因素，包括抗生素预防的影响。
回顾性单中心临床研究。
德国海德堡大学医院头颈外科三级转诊中心。
本研究纳入了 2007 年至 2014 年间在德国海德堡大学医院行腮腺手术的 754 例患者。收集了患者年龄、美国麻醉医师协会（ASA）分级系统、吸烟状况、糖尿病、手术时间和抗生素预防等数据。此外，还计算了国家医疗保健安全网络（NHSN）风险指数。在单因素分析和多因素逻辑回归模型中评估了这些因素与 SSI 的相关性。
SSI 发生率。
根据 NHSN 定义，24 例（3.2%）患者发生 SSI。单因素分析显示，只有吸烟者（P=0.048）和男性（P=0.01）的 SSI 发生率显著较高。由于大多数吸烟者为男性（62.3%），因此进一步在逻辑回归模型中研究了男性、吸烟以及 NHSN 风险指数作为 SSI 预测因子的作用。所有三个预测因子均对 SSI 有显著影响。
腮腺手术 SSI 发生率较低。在本队列中，男性、吸烟和 NHSN 风险指数评分高与 SSI 显著相关，而抗生素预防无保护作用。
