Bamdad Respiratory Research Center, Isfahan University of Medical Sciences, Esfahan, Iran.
Department of Medicine, Isfahan University of Medical Sciences, Esfahan, Iran.
Clin Respir J. 2021 Jul;15(7):770-778. doi: 10.1111/crj.13359. Epub 2021 Apr 4.
Non-invasive positive pressure ventilation (NIPPV) is known to enhance hypoventilation and is particularly adopted as a treatment for patients diagnosed with obesity hypoventilation syndrome (OHS). The augmented risk of cardiovascular morbidity is known as a side effect of OHS.
In this paper, this inference is examined that hypoventilation and the increased risk of morbidity can be diagnosed via the assessment of changes in heart rate variability (HRV). More specifically, the study investigates the effect of NIPPV on both HRV and hypoventilation among OHS patients. The linear relationship between different HRV measures and ventilation parameters is also examined.
MATERIALS & METHODS: The reported results are attained via an interventional clinical trial study. HRV measures are evaluated before and after treatment, in a group of patients which are newly diagnosed with OHS and receive bi-level positive airway pressure (BiPAP) treatment for three months.
The results are compared and interpreted via statistical analysis.
Throughout the study, the relationship between hypoventilation and HRV is confirmed, as well as the effect of BiPAP on some HRV measures in both time and frequency domains. Particularly significant connections are observed between hypoventilation and low-frequency components of HRV.
The enhanced respiration due to the application of BiPAP can improve the performance of autonomous nervous and cardiovascular systems, in terms of HRV. Moreover, it is suggested to consider some HRV parameters to control the cardiovascular side-effects of OHS and confine the resulting mortality rate in long term.
众所周知,无创正压通气(NIPPV)可增强通气不足,并特别适用于诊断为肥胖低通气综合征(OHS)的患者的治疗。OHS 的已知心血管发病率增加的风险是其副作用之一。
本文旨在通过评估心率变异性(HRV)的变化来检验这样一种推断,即低通气和发病率增加的风险可以通过评估来诊断。更具体地说,该研究调查了 NIPPV 对 OHS 患者的 HRV 和低通气的影响。还检查了不同 HRV 测量值与通气参数之间的线性关系。
通过一项干预性临床试验研究获得报告的结果。在一组新诊断为 OHS 并接受双水平气道正压通气(BiPAP)治疗三个月的患者中,在治疗前后评估 HRV 测量值。
通过统计分析比较和解释结果。
在整个研究过程中,确认了低通气与 HRV 之间的关系,以及 BiPAP 对时间和频率域中某些 HRV 测量值的影响。在低通气与 HRV 的低频成分之间观察到特别显著的关联。
由于应用 BiPAP 而增强的呼吸可以改善自主神经和心血管系统的 HRV 性能。此外,建议考虑一些 HRV 参数来控制 OHS 的心血管副作用,并限制长期的死亡率。