Wen Li-Rong, Wang Ning-Ning, Du Wu-Bo, Ma Qiang, Zhang Lin-Bao, Li Ming
State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
Org Biomol Chem. 2021 Apr 7;19(13):2895-2900. doi: 10.1039/d1ob00139f. Epub 2021 Mar 16.
The first nickel-catalyzed oxidative domino C-H/N-H double isocyanide insertion reaction of acetamides with isocyanides has been developed for the synthesis of pyrrolin-2-one derivatives. A wide range of acetamides bearing various functional groups are compatible with this reaction system by utilizing Ni(acac) as a catalyst. In this transformation, isocyanide could serve as a C1 connector and insert into the inactive C-H bond, representing an effective way to construct heterocycles.
已开发出首例镍催化的乙酰胺与异腈的氧化多米诺C-H/N-H双异腈插入反应，用于合成吡咯啉-2-酮衍生物。通过使用Ni(acac)作为催化剂，多种带有不同官能团的乙酰胺与该反应体系兼容。在这种转化中，异腈可作为C1连接体并插入惰性C-H键中，这是构建杂环的一种有效方法。
