Chronopoulos Argyrios, Mockenhaupt Maja, Pleyer Uwe
Klinik für Augenheilkunde, Klinikum Ludwigshafen, Ludwigshafen am Rhein, Deutschland.
Dokumentationszentrum schwerer Hautreaktionen (dZh), Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.
Ophthalmologe. 2021 May;118(5):519-532. doi: 10.1007/s00347-021-01351-2. Epub 2021 Mar 16.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe and often life-threatening reactions of the skin and mucous membranes. They are considered as a single disease entity with different expressions of severity and are summarized under the term epidermal necrolysis (EN). There is a high risk of ocular involvement, which can lead to long-lasting eye problems and even blindness without immediate ophthalmological treatment. The acute occurrence, the unpredictable course and extreme variation in the manifestation of complications require an interdisciplinary approach. A rapid diagnosis of eye involvement and initiation of an intensive lubricating and anti-inflammatory surface treatment is of utmost importance for the long-term outcome. This article should help ophthalmologists to have a better understanding of this condition and therefore lead to substantial improvement in visual outcome and the quality of life of patients.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是罕见的严重且常危及生命的皮肤和黏膜反应。它们被视为一种具有不同严重程度表现的单一疾病实体，并被归纳在表皮坏死松解症（EN）这一术语之下。眼部受累风险很高，若不立即进行眼科治疗，可能导致长期眼部问题甚至失明。并发症的急性发作、不可预测的病程以及表现的极端差异需要采取多学科方法。快速诊断眼部受累并开始强化的润滑和抗炎表面治疗对于长期预后至关重要。本文应有助于眼科医生更好地了解这种疾病，从而大幅改善患者的视觉预后和生活质量。
