Postgraduate Program in Surgery at the Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife, PE, 50670-901, Brazil.
Postgraduate Program in Nutrition at UFPE, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife, PE, 50670-901, Brazil.
Obes Surg. 2021 Jun;31(6):2723-2728. doi: 10.1007/s11695-021-05329-6. Epub 2021 Mar 16.
To evaluate the evolution of vitamin D levels (25OHD) in patients submitted to bariatric surgery.
Retrospective study, conducted with patients submitted to bariatric surgery between 2013 and 2018, in a city in the Northeast of Brazil. The variations of 25OHD, weight, body mass index (BMI), and total lymphocyte count were analyzed and compared for preoperative and postoperative periods of 6 and 12 months. Vitamin D levels below 30ng/mL were considered insufficient. Analysis of variance (ANOVA) was used for repeated measures, followed by Bonferroni post hoc test. To identify variables related to vitamin D, Pearson's correlation test and linear regression analysis were used. A significance level of 5% (p <0.05) was adopted.
A total of 646 patients were evaluated, with a mean age of 41.3 ± 10.8 years. Most of the patients were female (75%) and had 25OHD insufficiency in the preoperative period (79.1%). It was found that in the postoperative period there was an increase in vitamin D levels. Linear regression showed that the variation in vitamin D is negatively influenced by BMI in the preoperative period (β = -0.20; p = 0.02) and by BMI (β = -0.38; p <0.001) and by age (β = -0.08; p = 0.02) in the 6-month postoperative period.
There was an increase in vitamin D levels in the postoperative period. BMI proved to be a negative factor for obtaining adequate levels of vitamin D in the preoperative period and in the 6-month postoperative period.
评估接受减重手术患者的维生素 D 水平（25OHD）变化。
回顾性研究，纳入 2013 年至 2018 年间在巴西东北部某城市接受减重手术的患者。分析并比较了术前和术后 6 个月和 12 个月的 25OHD、体重、体重指数（BMI）和总淋巴细胞计数的变化。将 25OHD 水平低于 30ng/mL 定义为不足。采用重复测量方差分析（ANOVA），然后进行 Bonferroni 事后检验。采用 Pearson 相关检验和线性回归分析来识别与维生素 D 相关的变量。采用 5%的显著性水平（p＜0.05）。
共评估了 646 例患者，平均年龄为 41.3±10.8 岁。大多数患者为女性（75%），术前存在 25OHD 不足（79.1%）。术后发现维生素 D 水平升高。线性回归显示，维生素 D 的变化在术前受 BMI（β=-0.20；p=0.02）和术后 6 个月受 BMI（β=-0.38；p＜0.001）和年龄（β=-0.08；p=0.02）的负向影响。
术后维生素 D 水平升高。BMI 是术前和术后 6 个月获得足够维生素 D 水平的一个负面因素。
