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产妇意外硬脊膜穿刺后慢性疼痛:一项病例对照前瞻性观察研究。

Chronic pain in parturients with an accidental dural puncture: A case-controlled prospective observational study.

机构信息

Department of Anesthesiology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Faculty of Medicine, University of Zurich, Zurich, Switzerland.

出版信息

Acta Anaesthesiol Scand. 2021 Aug;65(7):959-966. doi: 10.1111/aas.13816. Epub 2021 Mar 24.

Abstract

BACKGROUND

We set out to examine incidence of chronic headache and back pain in women with PDPH after accidental dural puncture during labor.

METHODS

Chronic headache, backache, and disability were assessed 18-24 months postpartum. Women with PDPH treated with epidural blood patch (PDPH-EBP) were identified and matched with women who had a PDPH without epidural blood patch (PDPH-no EBP), with women with uncomplicated epidural analgesia and with women without epidural analgesia. Our primary outcome was incidence of chronic headache and backache. Secondary outcome was the effect of epidural blood patch on chronic pain development. We used Chi-square or Fisher's exact test to calculate odds ratios.

RESULTS

There was no statistically significant difference in demographic characteristics between groups. In the no epidural group, no women reported chronic headache and 2/116 (1.7%) reported chronic backache. In the uncomplicated epidural group, no women reported chronic headache and 7/116 (6.0%) reported chronic backache. In the PDPH-no EBP group, 9/56 (16.1%) women reported chronic headache and 10/56 (17.9%) reported chronic backache. In the PDPH-EBP group, 12/59 (20.3%) had chronic headache and 14/59 (23.7%) had chronic backache. No women in the no epidural or uncomplicated epidural group reported disability (chronic pain score of 3 or 4). High disability was reported by 8.9% of women in the PDPH-no EBP group and by 8.4% in the PDPH-EBP group.

CONCLUSION

Women with PDPH had a high incidence of chronic headache, back pain, and disability. We did not find a statistically significant difference in chronic pain development between conservatively treated and EBP-treated patients.

摘要

背景

我们旨在研究分娩时意外刺破硬脑膜后发生 PDPH 的女性慢性头痛和背痛的发生率。

方法

在产后 18-24 个月评估慢性头痛、背痛和残疾情况。确定并匹配接受硬膜外血补丁治疗的 PDPH 妇女(PDPH-EBP)、未接受硬膜外血补丁治疗的 PDPH 妇女(PDPH-no EBP)、接受单纯硬膜外镇痛的妇女和未接受硬膜外镇痛的妇女。我们的主要结局是慢性头痛和背痛的发生率。次要结局是硬膜外血补丁对慢性疼痛发展的影响。我们使用卡方或 Fisher 确切检验计算比值比。

结果

各组之间在人口统计学特征上无统计学差异。在未接受硬膜外组,无女性报告慢性头痛,116 例中有 2 例(1.7%)报告慢性背痛。在单纯硬膜外组,无女性报告慢性头痛,116 例中有 7 例(6.0%)报告慢性背痛。在 PDPH-no EBP 组,56 例中有 9 例(16.1%)女性报告慢性头痛,56 例中有 10 例(17.9%)报告慢性背痛。在 PDPH-EBP 组,59 例中有 12 例(20.3%)有慢性头痛,59 例中有 14 例(23.7%)有慢性背痛。未接受硬膜外或单纯硬膜外组无女性报告残疾(慢性疼痛评分 3 或 4)。PDPH-no EBP 组 8.9%的女性和 PDPH-EBP 组 8.4%的女性报告高残疾。

结论

患有 PDPH 的女性慢性头痛、背痛和残疾的发生率较高。我们未发现保守治疗和 EBP 治疗患者之间慢性疼痛发展存在统计学差异。

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